Quantifying axonal loss after optic neuritis with optical coherence tomography

Fiona Costello; Stuart Coupland; William Hodge; Gianni R Lorello; Jeannie Koroluk; Y Irene Pan; Mark S Freedman; David H Zackon; Randy H Kardon

doi:10.1002/ana.20851

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Quantifying axonal loss after optic neuritis with optical coherence tomography

Journal article

Peer reviewed

Quantifying axonal loss after optic neuritis with optical coherence tomography

Fiona Costello, Stuart Coupland, William Hodge, Gianni R Lorello, Jeannie Koroluk, Y Irene Pan, Mark S Freedman, David H Zackon and Randy H Kardon

Annals of neurology, Vol.59(6), pp.963-969

06/2006

DOI: 10.1002/ana.20851

PMID: 16718705

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Abstract

To determine to what degree changes in retinal nerve fiber layer (RNFL) thickness after optic neuritis (ON) correlate with either visual recovery or impairment. ON can cause visible defects within the RNFL, which can be quantified using optical coherence tomography (OCT). It may be possible to predict visual recovery by measuring RNFL loss after ON. Fifty-four patients underwent repeated evaluations with optical coherence tomography and standardized ophthalmic testing after ON. Regression analyses were used to determine the relationship between RNFL thickness and visual function. Thinning of the RNFL was seen in the majority of patients (74%), and it tended to occur within 3 to 6 months of ON. The average RNFL value was thinner (p<0.0001) in the affected (78 microm) compared with the unaffected eye (100 microm). Patients with incomplete visual recovery demonstrated greater RNFL loss after ON. Regression analyses demonstrated a threshold of RNFL thickness (75 microm), below which RNFL measurements predicted persistent visual dysfunction. Determination of RNFL thickness may predict visual recovery after ON, and lower RNFL values correlate with impaired visual function. Optical coherence tomography may have a potential role as a surrogate marker for axonal integrity within the optic nerve among patients with ON.

Prognosis

Prospective Studies

Tomography, Optical Coherence

Humans

Middle Aged

Male

Vision Tests

Recovery of Function

Vision Disorders - diagnosis

Visual Fields

Axons - pathology

Adolescent

Adult

Female

Nerve Degeneration - diagnosis

Nerve Degeneration - etiology

Optic Neuritis - pathology

Retina - pathology

Optic Neuritis - complications

Vision Disorders - etiology

Details

Title: Subtitle: Quantifying axonal loss after optic neuritis with optical coherence tomography
Creators: Fiona Costello - Division of Neurology, Ottawa, Ontario Canada. fcostello@ottawahospital.on.ca
Stuart Coupland
William Hodge
Gianni R Lorello
Jeannie Koroluk
Y Irene Pan
Mark S Freedman
David H Zackon
Randy H Kardon
Resource Type: Journal article
Publication Details: Annals of neurology, Vol.59(6), pp.963-969
DOI: 10.1002/ana.20851
PMID: 16718705
NLM abbreviation: Ann Neurol
ISSN: 0364-5134
eISSN: 1531-8249
Publisher: United States
Grant note: R01EY017066-01 / NEI NIH HHS
Language: English
Date published: 06/2006
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980034602771

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