Journal article
Quantifying regional hypoxia in human tumors with positron emission tomography of [ 18F]fluoromisonidazole: A pretherapy study of 37 patients
International journal of radiation oncology, biology, physics, Vol.36(2), pp.417-428
1996
DOI: 10.1016/S0360-3016(96)00325-2
PMID: 8892467
Abstract
Purpose: To assess pretreatment hypoxia in a variety of tumors using positron emission tomography (PET) after injection of the hypoxia-binding radiopharmaceutical [18F]fluoromisonidazole ([18F]FMISO).
Methods and materials: Tumor fractional hypoxic volume (FHV) was determined in 21 nonsmall cell lung cancer patients, 7 head and neck cancer patients, 4 prostate cancer patients, and 5 patients with other malignancies by quantitative PET imaging after injection of [18F]FMISO (0.1 mCi/kg). The FHV was defined as the proportion of pixels in the imaged tumor volume with a tissue:blood [18F] activity ratio > or = 1.4 at 120-160 min postinjection. A FHV > 0 was taken as evidence for tumor hypoxia.
Results: Hypoxia was observed in 36 of 37 tumors studied with FMISO PET imaging; FHVs ranged from 0 to 94.7%. In nonsmall cell lung cancers (n = 21), the median FHV was 47.6% and the range, 1.3 to 94.7%. There was no correlation between tumor size and FHV. In the seven head and neck carcinomas, the median FHV was 8.8%, with a range from 0.2 to 18.9%. In the group of four prostate cancers, the median and range were 18.2% and 0 to 93.9%, while in a group of five tumors of different types the median FHV was 55.2% (range: 21.4 to 85.8%).
Conclusions: Hypoxia was present in 97% of the tumors studied and the extent of hypoxia varied markedly between tumors in the same site or of the same histology. Hypoxia also was distributed heterogeneously between regions within a single tumor. These results are consistent with O2 electrode measures with other types of human tumors. The intra- and intertumor variability indicate the importance of making oxygenation measures in individual tumors and the necessity to sample as much of the tumor volume as possible.
Details
- Title: Subtitle
- Quantifying regional hypoxia in human tumors with positron emission tomography of [ 18F]fluoromisonidazole: A pretherapy study of 37 patients
- Creators
- Janet S Rasey - Department of Radiation Oncology, University of Washington, Seattle, WA, USAWui-jin Koh - Department of Radiation Oncology, University of Washington, Seattle, WA, USAMargaret L Evans - Department of Radiation Oncology, University of Washington, Seattle, WA, USALanell M Peterson - Department of Radiation Oncology, University of Washington, Seattle, WA, USAThomas K Lewellen - Department of Radiology, University of Washington, Seattle, WA, USAMichael M Graham - Department of Radiation Oncology, University of Washington, Seattle, WA, USAKenneth A Krohn - Department of Radiation Oncology, University of Washington, Seattle, WA, USA
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.36(2), pp.417-428
- DOI
- 10.1016/S0360-3016(96)00325-2
- PMID
- 8892467
- NLM abbreviation
- Int J Radiat Oncol Biol Phys
- ISSN
- 0360-3016
- eISSN
- 1879-355X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1996
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984047642802771
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