Journal article
Quantifying the Onset of Unintended Weight Loss in Huntington's Disease: A Retrospective Analysis of Enroll-HD
Journal of Huntington's disease, Vol.10(4), pp.485-492
2021
DOI: 10.3233/JHD-210488
PMCID: PMC8865202
PMID: 34633327
Abstract
Unintended weight loss and decreased body mass indexes (BMIs) are common symptoms of individuals with manifest HD. It is unknown at what point during disease progression weight loss starts to accelerate relative to a healthy individual's weight and when recommended interventions should be initiated to have the strongest impact on patient care.
The objective of this study was to identify a point in time relative to age at motor onset when the decline in weight in HD starts to accelerate relative to a non-HD population. The relationship between initiation of weight loss interventions and changes in weight loss was also explored.
Participants from the fifth version of the Enroll-HD study were identified for this research. Linear mixed-effects piecewise regression models were used to estimate the point in time relative to the reported age of motor onset in which BMI started to decline in participants with HD compared to healthy non-HD controls. A post-hoc descriptive analysis was performed to look at when nutritional supplements and swallow therapy were initiated in participants with HD relative to motor onset.
BMI decline in the HD group began to accelerate compared to controls approximately 5.7 years after the reported age of motor onset (95% CI: 4.7-6.9). The average initiation times of swallow therapy and nutritional supplements were 7.7 years (SD = 5.5 years) and 6.7 years (SD = 6.5 years) after motor onset, respectively.
Our findings suggest a potential point for intervention of nutrition programs or therapies used to prevent future weight loss.
Details
- Title: Subtitle
- Quantifying the Onset of Unintended Weight Loss in Huntington's Disease: A Retrospective Analysis of Enroll-HD
- Creators
- Amy C Ogilvie - Department of Epidemiology, The College of Public Health, The University of Iowa, Iowa City, IA, USAPeg C Nopoulos - Stead Family Department of Pediatrics, The University of Iowa Hospitals and Clinics, Iowa City, IA, USAJordan L Schultz - Division of Pharmacy Practice and Sciences, The College of Pharmacy, The University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of Huntington's disease, Vol.10(4), pp.485-492
- DOI
- 10.3233/JHD-210488
- PMID
- 34633327
- PMCID
- PMC8865202
- NLM abbreviation
- J Huntingtons Dis
- ISSN
- 1879-6397
- eISSN
- 1879-6400
- Language
- English
- Date published
- 2021
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Pharmacy Practice and Science
- Record Identifier
- 9984209489802771
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