Journal article
Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography
Investigative ophthalmology & visual science, Vol.54(10), pp.6846-6851
10/21/2013
DOI: 10.1167/iovs.13-12062
PMCID: PMC5963175
PMID: 24045992
Abstract
Purpose.: To investigate the optical intensities of all retinal layers on three-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) in normal subjects using an automatic measurement.
Methods.: Forty normal subjects underwent Topcon 3D OCT-1000 macula-centered scan. The raw data were automatically segmented into 10 layers using the 3D graph search approach. Then the mean and standard deviation of intensities of each layer were calculated. The image quality index was given by the OCT software. Correlation analysis was performed between the optical intensities in each layer and image quality and subject's age.
Results.: The correlation of optical intensities was strong from ganglion cell layer (GCL) to outer nuclear layer (ONL) with r > 0.934; moderate among retinal nerve fiber layer (RNFL), photoreceptor, retinal pigment epithelium (RPE), and choroid (0.410 < r < 0.800); and low in the vitreous (0.251 < r < 0.541). The optical intensities were also correlated with the image quality, r > 0.869 from GCL to ONL, 0.748 < r < 0.802 for RNFL, photoreceptor layer, RPE, and the choroid, r = 0.528 for the vitreous. The optical intensity in RNFL was negatively correlated with age (r = −0.365).
Conclusions.: Automatic assessment of the layers' intensities was achieved. In normal subjects, the retinal layers' optical intensities were affected by image quality. Normalization with optical intensity of ONL, all areas, or image quality index is recommended. The optical intensity of RNFL decreased with age.
Details
- Title: Subtitle
- Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography
- Creators
- Xinjian Chen - School of Electronics and Information Engineering, Soochow University, Suzhou, ChinaPing Hou - Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, ChinaChao Jin - School of Electronics and Information Engineering, Soochow University, Suzhou, ChinaWeifang Zhu - School of Electronics and Information Engineering, Soochow University, Suzhou, ChinaXiaohong Luo - Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, ChinaFei Shi - School of Electronics and Information Engineering, Soochow University, Suzhou, ChinaMilan Sonka - Iowa Institute for Biomedical Imaging and Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IowaHaoyu Chen - Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, China 4Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Hong Kong, China
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.54(10), pp.6846-6851
- DOI
- 10.1167/iovs.13-12062
- PMID
- 24045992
- PMCID
- PMC5963175
- NLM abbreviation
- Invest Ophthalmol Vis Sci
- ISSN
- 1552-5783
- eISSN
- 1552-5783
- Language
- English
- Date published
- 10/21/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984047979502771
Metrics
35 Record Views