Quantitative CT-based structural alterations of segmental airways in cement dust-exposed subjects

Taewoo Kim; Hyun Bin Cho; Woo Jin Kim; Chang Hyun Lee; Kum Ju Chae; So-Hyun Choi; Kyeong Eun Lee; So Hyeon Bak; Sung Ok Kwon; Gong Yong Jin; Jiwoong Choi; Eun-Kee Park; Ching-Long Lin; Eric A Hoffman; Sanghun Choi

doi:10.1186/s12931-020-01399-9

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Quantitative CT-based structural alterations of segmental airways in cement dust-exposed subjects

Journal article

Open access

Peer reviewed

Quantitative CT-based structural alterations of segmental airways in cement dust-exposed subjects

Taewoo Kim, Hyun Bin Cho, Woo Jin Kim, Chang Hyun Lee, Kum Ju Chae, So-Hyun Choi, Kyeong Eun Lee, So Hyeon Bak, Sung Ok Kwon, Gong Yong Jin, …

Respiratory research, Vol.21(1), pp.133-133

05/29/2020

DOI: 10.1186/s12931-020-01399-9

PMCID: PMC7260806

PMID: 32471435

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Abstract

Dust exposure has been reported as a risk factor of pulmonary disease, leading to alterations of segmental airways and parenchymal lungs. This study aims to investigate alterations of quantitative computed tomography (QCT)-based airway structural and functional metrics due to cement-dust exposure. To reduce confounding factors, subjects with normal spirometry without fibrosis, asthma and pneumonia histories were only selected, and a propensity score matching was applied to match age, sex, height, smoking status, and pack-years. Thus, from a larger data set (N = 609), only 41 cement dust-exposed subjects were compared with 164 non-cement dust-exposed subjects. QCT imaging metrics of airway hydraulic diameter (D ), wall thickness (WT), and bifurcation angle (θ) were extracted at total lung capacity (TLC) and functional residual capacity (FRC), along with their deformation ratios between TLC and FRC. In TLC scan, dust-exposed subjects showed a decrease of D (airway narrowing) especially at lower-lobes (p < 0.05), an increase of WT (wall thickening) at all segmental airways (p < 0.05), and an alteration of θ at most of the central airways (p < 0.001) compared with non-dust-exposed subjects. Furthermore, dust-exposed subjects had smaller deformation ratios of WT at the segmental airways (p < 0.05) and θ at the right main bronchi and left main bronchi (p < 0.01), indicating airway stiffness. Dust-exposed subjects with normal spirometry demonstrated airway narrowing at lower-lobes, wall thickening at all segmental airways, a different bifurcation angle at central airways, and a loss of airway wall elasticity at lower-lobes. The airway structural alterations may indicate different airway pathophysiology due to cement dusts.

Dust - analysis

Humans

Middle Aged

Respiratory Function Tests - methods

Tomography, X-Ray Computed - methods

Male

Environmental Exposure - analysis

Total Lung Capacity - physiology

Pulmonary Disease, Chronic Obstructive - epidemiology

Environmental Exposure - adverse effects

Pulmonary Disease, Chronic Obstructive - chemically induced

Adult

Female

Pulmonary Disease, Chronic Obstructive - diagnostic imaging

Aged

Retrospective Studies

Bronchi - diagnostic imaging

Details

Title: Subtitle: Quantitative CT-based structural alterations of segmental airways in cement dust-exposed subjects
Creators: Taewoo Kim - School of Mechanical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea
Hyun Bin Cho - School of Mechanical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea
Woo Jin Kim - Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea
Chang Hyun Lee - Department of Radiology, College of Medicine, The University of Iowa, Iowa City, Iowa, USA
Kum Ju Chae - Department of Radiology, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea
So-Hyun Choi - Department of Statistics, Kyungpook National University, Daegu, South Korea
Kyeong Eun Lee - Department of Statistics, Kyungpook National University, Daegu, South Korea
So Hyeon Bak - Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea
Sung Ok Kwon - Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea
Gong Yong Jin - Department of Radiology, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea
Jiwoong Choi - IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa, USA
Eun-Kee Park - Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University, Busan, South Korea
Ching-Long Lin - IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa, USA
Eric A Hoffman - Department of Radiology, College of Medicine, The University of Iowa, Iowa City, Iowa, USA
Sanghun Choi - School of Mechanical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea. s-choi@knu.ac.kr
Resource Type: Journal article
Publication Details: Respiratory research, Vol.21(1), pp.133-133
DOI: 10.1186/s12931-020-01399-9
PMID: 32471435
PMCID: PMC7260806
NLM abbreviation: Respir Res
ISSN: 1465-993X
eISSN: 1465-993X
Publisher: England
Grant note: RE201806039 / Ministry of Environment (KR) RE201806027 / Ministry of Environment (KR) NRF-2017R1D1A1B03034157 / Ministry of Education (KR)
Language: English
Date published: 05/29/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
Record Identifier: 9984066337902771

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