Journal article
Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma
Curēus (Palo Alto, CA), Vol.7(11), p.e379
11/13/2015
DOI: 10.7759/cureus.379
PMCID: PMC4689559
PMID: 26719822
Abstract
Neurolymphomatosis (NL) is a rare disease characterized by malignant lymphocytes infiltrating various structures of the nervous system. It typically manifests as a neuropathy involving the peripheral nerves, nerve roots, plexuses, or cranial nerves. It often presents as a complication of lymphoma, but it can be the presenting feature of recurrent lymphoma. It is essential to identify and initiate treatment early with chemotherapy and/or radiation therapy in all cases of nodal or visceral (including neural) involvement with lymphoma. There are various diagnostic tests that can be used for its detection, such as cerebrospinal spinal fluid (CSF) cytology, electromyography (EMG), magnetic resonance imaging (MRI), and positron-emission tomography/computed tomography (PET/CT). FDG-PET/CT is the standard of care in lymphoma staging, restaging, and therapy response assessment, but has an inherent limitation in the detection of disease involvement in the central nervous system. While that is mostly true for visual assessment, there are quantitative methods to measure variation in the metabolic activity in the brain, which in turn helps detect the occurrence of neurolymphomatosis.
Details
- Title: Subtitle
- Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma
- Creators
- Faiq Shaikh - University of IowaDerek Savells - Imaging Informatics, University of Pittsburgh Medical Center Molecular Imaging Physician, S&L Readings, LLC. Department of Radiology, University of Iowa Hospitals and Clinics Department of Radiology, Dartmouth Hitchcock Medical Center Department of Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, N.Y., USA Neuroradiology, Johns Hopkins University School of Medicine Department of Neurosurgery, University of Iowa Hospitals and ClinicsOmer Awan - University of IowaFaisal Inayat - Imaging Informatics, University of Pittsburgh Medical Center Molecular Imaging Physician, S&L Readings, LLC. Department of Radiology, University of Iowa Hospitals and Clinics Department of Radiology, Dartmouth Hitchcock Medical Center Department of Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, N.Y., USA Neuroradiology, Johns Hopkins University School of Medicine Department of Neurosurgery, University of Iowa Hospitals and ClinicsAmmar Chaudhry - Imaging Informatics, University of Pittsburgh Medical Center Molecular Imaging Physician, S&L Readings, LLC. Department of Radiology, University of Iowa Hospitals and Clinics Department of Radiology, Dartmouth Hitchcock Medical Center Department of Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, N.Y., USA Neuroradiology, Johns Hopkins University School of Medicine Department of Neurosurgery, University of Iowa Hospitals and ClinicsNivedita Jerath - Imaging Informatics, University of Pittsburgh Medical Center Molecular Imaging Physician, S&L Readings, LLC. Department of Radiology, University of Iowa Hospitals and Clinics Department of Radiology, Dartmouth Hitchcock Medical Center Department of Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, N.Y., USA Neuroradiology, Johns Hopkins University School of Medicine Department of Neurosurgery, University of Iowa Hospitals and ClinicsMichael M Graham - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Curēus (Palo Alto, CA), Vol.7(11), p.e379
- DOI
- 10.7759/cureus.379
- PMID
- 26719822
- PMCID
- PMC4689559
- NLM abbreviation
- Cureus
- ISSN
- 2168-8184
- eISSN
- 2168-8184
- Publisher
- Cureus
- Language
- English
- Date published
- 11/13/2015
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984314281002771
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