Quantitative MR measures of intrarenal perfusion in the assessment of transplanted kidneys: initial experience

Andrew L Wentland; Elizabeth A Sadowski; Arjang Djamali; Thomas M Grist; Bryan N Becker; Sean B Fain

doi:10.1016/j.acra.2009.03.020

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Quantitative MR measures of intrarenal perfusion in the assessment of transplanted kidneys: initial experience

Journal article

Peer reviewed

Quantitative MR measures of intrarenal perfusion in the assessment of transplanted kidneys: initial experience

Andrew L Wentland, Elizabeth A Sadowski, Arjang Djamali, Thomas M Grist, Bryan N Becker and Sean B Fain

Academic radiology, Vol.16(9), pp.1077-1085

09/2009

DOI: 10.1016/j.acra.2009.03.020

PMCID: PMC2749559

PMID: 19539502

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Abstract

The purpose of this study was to evaluate prospectively a gadolinium-based perfusion technique for intrarenal blood flow in transplanted kidneys and to determine if magnetic resonance imaging (MRI) measurements of intrarenal perfusion could be used to differentiate between normal-functioning kidney allografts and allografts with acute tubular necrosis (ATN) or acute rejection. Twenty-one subjects were enrolled within 4 months of receiving a kidney transplant. A biopsy was performed on subjects to diagnose each allograft as having either ATN or acute rejection. A group of subjects with normal functioning transplants was also enrolled in our study. MRI perfusion images were acquired on a 1.5 T MRI system within 48 hours after biopsy using an echo planar, T2*-weighted sequence, and an injection of gadodiamide contrast agent administered at a dose of 0.1 mmol/kg. Scan parameters were: repetition time/echo time/flip = 1000 ms/30 ms/60 degrees , field of view = 340 x 340 mm, matrix = 128 x 64, slice thickness = 10 mm, and temporal resolution = 1.0 seconds. Cortical and medullary blood flow values were calculated. Medullary blood flow values were significantly (P = .02) lower in allografts undergoing acute rejection (121 +/- 41 mL/100 g/min) compared to normal-functioning allografts (221 +/- 96 mL/100 g/min) and those with ATN (247 +/- 124 mL/100 g/min). Cortical blood flow values were also significantly (P = .03) reduced in allografts with acute rejection (243 +/- 116 mL/100 g/min) compared to those with normal function (413 +/- 116 mL/100 g/min). Preliminary results indicate that MRI perfusion techniques may provide a means of determining noninvasively the viability of renal allografts, potentially alleviating the need for biopsy in some patients.

Adult

Aged

Blood Flow Velocity

Female

Gadolinium DTPA

Humans

Image Interpretation, Computer-Assisted - methods

Kidney - blood supply

Kidney - physiopathology

Kidney Transplantation - pathology

Magnetic Resonance Imaging - methods

Male

Middle Aged

Perfusion Imaging

Pilot Projects

Regional Blood Flow

Young Adult

Details

Title: Subtitle: Quantitative MR measures of intrarenal perfusion in the assessment of transplanted kidneys: initial experience
Creators: Andrew L Wentland - University of Wisconsin–Madison
Elizabeth A Sadowski - University of Wisconsin–Madison
Arjang Djamali - University of Wisconsin–Madison
Thomas M Grist - University of Wisconsin–Madison
Bryan N Becker - University of Wisconsin–Madison
Sean B Fain - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Academic radiology, Vol.16(9), pp.1077-1085
DOI: 10.1016/j.acra.2009.03.020
PMID: 19539502
PMCID: PMC2749559
NLM abbreviation: Acad Radiol
ISSN: 1076-6332
eISSN: 1878-4046
Grant note: R01 DK073680 / NIDDK NIH HHS T32 GM008692 / NIGMS NIH HHS R01 DK073680-03 / NIDDK NIH HHS
Language: English
Date published: 09/2009
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
Record Identifier: 9984275057802771

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