Journal article
Quantitative MRI for the assessment of bone structure and function
NMR in biomedicine, Vol.19(7), pp.731-764
11/2006
DOI: 10.1002/nbm.1066
PMID: 17075953
Abstract
Osteoporosis is the most common degenerative disease in the elderly. It is characterized by low bone mass and structural deterioration of bone tissue, leading to morbidity and increased fracture risk in the hip, spine and wrist-all sites of predominantly trabecular bone. Bone densitometry, currently the standard methodology for diagnosis and treatment monitoring, has significant limitations in that it cannot provide information on the structural manifestations of the disease. Recent advances in imaging, in particular MRI, can now provide detailed insight into the architectural consequences of disease progression and regression in response to treatment. The focus of this review is on the emerging methodology of quantitative MRI for the assessment of structure and function of trabecular bone. During the past 10 years, various approaches have been explored for obtaining image-based quantitative information on trabecular architecture. Indirect methods that do not require resolution on the scale of individual trabeculae and therefore can be practiced at any skeletal location, make use of the induced magnetic fields in the intertrabecular space. These fields, which have their origin in the greater diamagnetism of bone relative to surrounding marrow, can be measured in various ways, most typically in the form of R2', the recoverable component of the total transverse relaxation rate. Alternatively, the trabecular network can be quantified by high-resolution MRI (micro-MRI), which requires resolution adequate to at least partially resolve individual trabeculae. Micro-MRI-based structure analysis is therefore technically demanding in terms of image acquisition and algorithms needed to extract the structural information under conditions of limited signal-to-noise ratio and resolution. Other requirements that must be met include motion correction and image registration, both critical for achieving the reproducibility needed in repeat studies. Key clinical applications targeted involve fracture risk prediction and evaluation of the effect of therapeutic intervention.
Details
- Title: Subtitle
- Quantitative MRI for the assessment of bone structure and function
- Creators
- Felix W Wehrli - Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA. wehrlif@uphs.upenn.eduHee Kwon SongPunam K SahaAlexander C Wright
- Resource Type
- Journal article
- Publication Details
- NMR in biomedicine, Vol.19(7), pp.731-764
- DOI
- 10.1002/nbm.1066
- PMID
- 17075953
- NLM abbreviation
- NMR Biomed
- ISSN
- 0952-3480
- eISSN
- 1099-1492
- Publisher
- England
- Grant note
- R01 AR49553 / NIAMS NIH HHS R01 AR41443 / NIAMS NIH HHS R01 AR40671 / NIAMS NIH HHS R01 AR53156 / NIAMS NIH HHS
- Language
- English
- Date published
- 11/2006
- Academic Unit
- Radiology; Electrical and Computer Engineering
- Record Identifier
- 9984051740102771
Metrics
15 Record Views