Quantitative Magnetic Resonance Imaging of Pulmonary Hypertension A Practical Approach to the Current State of the Art

Andrew J. Swift; Jim M. Wild; Scott K. Nagle; Alejandro Roldan-Alzate; Christopher J. Francois; Sean Fain; Kevin Johnson; Dave Capener; Edwin J. R. van Beek; David G. Kiely; Kang Wang; Mark L. Schiebler

doi:10.1097/RTI.0000000000000079

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Quantitative Magnetic Resonance Imaging of Pulmonary Hypertension A Practical Approach to the Current State of the Art

Journal article

Peer reviewed

Quantitative Magnetic Resonance Imaging of Pulmonary Hypertension A Practical Approach to the Current State of the Art

Andrew J. Swift, Jim M. Wild, Scott K. Nagle, Alejandro Roldan-Alzate, Christopher J. Francois, Sean Fain, Kevin Johnson, Dave Capener, Edwin J. R. van Beek, David G. Kiely, …

Journal of thoracic imaging, Vol.29(2), pp.68-79

03/01/2014

DOI: 10.1097/RTI.0000000000000079

PMCID: PMC4015452

PMID: 24552882

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https://www.ncbi.nlm.nih.gov/pmc/articles/4015452View

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Abstract

Pulmonary hypertension is a condition of varied etiology, commonly associated with poor clinical outcome. Patients are categorized on the basis of pathophysiological, clinical, radiologic, and therapeutic similarities. Pulmonary arterial hypertension (PAH) is often diagnosed late in its disease course, with outcome dependent on etiology, disease severity, and response to treatment. Recent advances in quantitative magnetic resonance imaging (MRI) allow for better initial characterization and measurement of the morphologic and flow-related changes that accompany the response of the heart-lung axis to prolonged elevation of pulmonary arterial pressure and resistance and provide a reproducible, comprehensive, and noninvasive means of assessing the course of the disease and response to treatment. Typical features of PAH occur primarily as a result of increased pulmonary vascular resistance and the resultant increased right ventricular (RV) afterload. Several MRI-derived diagnostic markers have emerged, such as ventricular mass index, interventricular septal configuration, and average pulmonary artery velocity, with diagnostic accuracy similar to that of Doppler echocardiography. Furthermore, prognostic markers have been identified with independent predictive value for identification of treatment failure. Such markers include large RV end-diastolic volume index, low left ventricular end-diastolic volume index, low RV ejection fraction, and relative area change of the pulmonary trunk. MRI is ideally suited for longitudinal follow-up of patients with PAH because of its noninvasive nature and high reproducibility and is advantageous over other biomarkers in the study of PAH because of its sensitivity to change in morphologic, functional, and flow-related parameters. Further study on the role of MRI image based biomarkers in the clinical environment is warranted.

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: Quantitative Magnetic Resonance Imaging of Pulmonary Hypertension A Practical Approach to the Current State of the Art
Creators: Andrew J. Swift - University of Wisconsin–Madison
Jim M. Wild - Univ Sheffield, Dept Cardio Vasc Sci, Acad Unit Radiol, Sheffield S10 2TN, S Yorkshire, England
Scott K. Nagle - University of Wisconsin–Madison
Alejandro Roldan-Alzate - University of Wisconsin–Madison
Christopher J. Francois - University of Wisconsin–Madison
Sean Fain - University of Wisconsin–Madison
Kevin Johnson - University of Wisconsin–Madison
Dave Capener - Univ Sheffield, Dept Cardio Vasc Sci, Acad Unit Radiol, Sheffield S10 2TN, S Yorkshire, England
Edwin J. R. van Beek - West Midlands Deanery
David G. Kiely - Royal Hammashire Hosp, Sheffield Pulm Vasc Dis Unit, Sheffield, S Yorkshire, England
Kang Wang - Adv Sci Lab, Gen Elect Med Syst, Madison, WI 53706 USA
Mark L. Schiebler - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Journal of thoracic imaging, Vol.29(2), pp.68-79
DOI: 10.1097/RTI.0000000000000079
PMID: 24552882
PMCID: PMC4015452
NLM abbreviation: J Thorac Imaging
ISSN: 0883-5993
eISSN: 1536-0237
Publisher: Lippincott Williams & Wilkins
Number of pages: 12
Grant note: KL2 TR000428; UL1 TR000427 / NCATS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) NIHR-RP-R3-12-027 / National Institute for Health Research; National Institute for Health Research (NIHR) UL1TR000427 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) G0701127 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) NIHR-RP-R3-12-027; BRF-2011-023 / Department of Health; European Commission G0701127 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission
Language: English
Date published: 03/01/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
Record Identifier: 9984275058302771

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