Journal article
Quantitative Measurements of Cerebral Blood Flow in Patients With Unilateral Carotid Artery Occlusion: A PET and MR Study
Journal of magnetic resonance imaging, Vol.14(6), pp.659-667
12/2001
DOI: 10.1002/jmri.10021
PMCID: PMC4102701
PMID: 11747021
Abstract
Although it has been demonstrated that quantitative measures of cerebral blood flow (CBF) can be obtained with the singular value decomposition (SVD) algorithm, the extent to which quantitative CBF measurements can be utilized under pathophysiological conditions has not been systematically studied. A total of five healthy volunteers and five patients with unilateral carotid artery occlusion were studied. Only magnetic resonance (MR) images were acquired for the volunteer group while both MR and positron emission tomography (PET) images were acquired for the patient group. Assessments of CBF from normal volunteers compared favorably with values reported in the literature. However, while a linear relationship was observed for each patient when MR measured CBF was compared to that obtained from PET, this linear relationship diminished when all patients were analyzed as a group (r = 0.41). A correction factor (CF) was proposed that was equal to the ratio of the area of the venous output function (VOF) in each patient to the mean VOF obtained from the volunteer group. After globally scaling the CBF of each patient based on the experimentally derived CF, a substantial improvement was observed (a slope of 1.02 and r = 0.8 for the linear regression line) in the relationship between MR estimated CBF and those obtained from PET.
Details
- Title: Subtitle
- Quantitative Measurements of Cerebral Blood Flow in Patients With Unilateral Carotid Artery Occlusion: A PET and MR Study
- Creators
- Weili Lin - Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North CarolinaAzim Celik - Department of Electrical Engineering, Washington University, St. Louis, MissouriColin Derdeyn - Department of Radiology, Washington University, St. Louis, MissouriHongyu An - Department of Biomedical Engineering, Washington University, St. Louis, MissouriYueh Lee - Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North CarolinaTom Videen - Department of Neurology, Washington University, St. Louis, MissouriLeif Ostergaard - Department of Neuroradiology, Aarhus University Hospital, Aarhus, DenmarkWilliam J Powers - Department of Radiology, Washington University, St. Louis, Missouri
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.14(6), pp.659-667
- DOI
- 10.1002/jmri.10021
- PMID
- 11747021
- PMCID
- PMC4102701
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Language
- English
- Date published
- 12/2001
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020738102771
Metrics
25 Record Views