Journal article
Quantitative Surface-Enhanced Spectroscopy
Annual review of physical chemistry, Vol.73(1), pp.141-162
12/22/2021
DOI: 10.1146/annurev-physchem-082720-033751
PMID: 34936809
Abstract
Surface-enhanced Raman scattering (SERS), a powerful technique for trace molecular detection, depends on chemical and electromagnetic enhancements. While recent advances in instrumentation and substrate design have expanded the utility, reproducibility, and quantitative capabilities of SERS, some challenges persist. In this review, advances in quantitative SERS detection are discussed as they relate to intermolecular interactions, surface selection rules, and target molecule solubility and accessibility. After a brief introduction to Raman scattering and SERS, impacts of surface selection rules and enhancement mechanisms are discussed as they relate to the observation of activation and deactivation of normal Raman modes in SERS. Next, experimental conditions that can be used to tune molecular affinity to and density near SERS substrates are summarized and considered while tuning these parameters are conveyed. Finally, successful examples of quantitative SERS detection are discussed, and future opportunities are outlined. Expected final online publication date for the
, Volume 73 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Details
- Title: Subtitle
- Quantitative Surface-Enhanced Spectroscopy
- Creators
- Ryan D Norton - Department of Chemistry, University of Iowa, Iowa City, Iowa, USA; email: amanda-haes@uiowa.eduHoa T Phan - Department of Chemistry, University of Iowa, Iowa City, Iowa, USA; email: amanda-haes@uiowa.eduStephanie N Gibbons - Department of Chemistry, University of Iowa, Iowa City, Iowa, USA; email: amanda-haes@uiowa.eduAmanda J Haes - Department of Chemistry, University of Iowa, Iowa City, Iowa, USA; email: amanda-haes@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Annual review of physical chemistry, Vol.73(1), pp.141-162
- DOI
- 10.1146/annurev-physchem-082720-033751
- PMID
- 34936809
- NLM abbreviation
- Annu Rev Phys Chem
- ISSN
- 0066-426X
- eISSN
- 1545-1593
- Language
- English
- Date published
- 12/22/2021
- Academic Unit
- Anesthesia; Chemistry
- Record Identifier
- 9984217558402771
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