Journal article
Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography for central retinal artery occlusion
Scientific reports, Vol.5(1), pp.9269-9269
03/18/2015
DOI: 10.1038/srep09269
PMCID: PMC4363859
PMID: 25784298
Abstract
Optical coherence tomography (OCT) provides not only morphological information but also information about layer-specific optical intensities, which may represent the underlying tissue properties. The purpose of this study is to quantitatively investigate the optical intensity of each retinal layers in central retinal artery occlusion (CRAO). Twenty-nine CRAO cases at acute phase and 33 normal controls were included. Macula-centered 3D OCT images were segmented with a fully-automated Iowa Reference Algorithm into 10 layers. Layer-specific mean intensities were determined and compared between the patient and control groups using multiple regression analysis while adjusting for age and optical intensity of the entire region. The optical intensities were higher in CRAO than in controls in layers spanning from the retinal ganglion cell layer to outer plexiform layer (standardized beta = 0.657 to 0.777, all p < 0.001), possibly due to ischemia. Optical intensities were lower at the photoreceptor, retinal pigment epithelium (RPE), and choroid layers (standardized beta = -0.412 to -0.611, all p < 0.01), possibly due to shadowing effects. Among the intraretinal layers, the inner nuclear layer was identified as the best indicator of CRAO. Our study provides in vivo information of the optical intensity changes in each retinal layer in CRAO patients.
Details
- Title: Subtitle
- Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography for central retinal artery occlusion
- Creators
- Haoyu Chen - Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, ChinaXinjian Chen - School of Electronics and Information Engineering, Soochow University, Suzhou, ChinaZhiqiao Qiu - Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, ChinaDehui Xiang - School of Electronics and Information Engineering, Soochow University, Suzhou, ChinaWeiqi Chen - Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, ChinaFei Shi - School of Electronics and Information Engineering, Soochow University, Suzhou, ChinaJianlong Zheng - Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, ChinaWeifang Zhu - School of Electronics and Information Engineering, Soochow University, Suzhou, ChinaMilan Sonka - Iowa Institute for Biomedical Imaging and Department of Electrical and Computer Engineering, University of Iowa, Iowa, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.5(1), pp.9269-9269
- DOI
- 10.1038/srep09269
- PMID
- 25784298
- PMCID
- PMC4363859
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- England
- Grant note
- R01-EB004640 / NIBIB NIH HHS R01-EY018853 / NEI NIH HHS R01 EB004640 / NIBIB NIH HHS R01 EY018853 / NEI NIH HHS R01 EY019112 / NEI NIH HHS R01-EY019112 / NEI NIH HHS
- Language
- English
- Date published
- 03/18/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984047744502771
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