Journal article
Quantitative and Semiquantitative Measures of Regional Pulmonary Microvascular Perfusion by Magnetic Resonance Imaging and Their Relationships to Global Lung Perfusion and Lung Diffusing Capacity: The Multiethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease Study
Investigative radiology, Vol.48(4), pp.223-230
04/2013
DOI: 10.1097/RLI.0b013e318281057d
PMID: 23385398
Abstract
OBJECTIVESThe aim of this study was to evaluate the quantitative and semiquantitative measures of regional pulmonary parenchymal perfusion in patients with chronic obstructive pulmonary disease (COPD) in relationship to global lung perfusion (GLP) and lung diffusing capacity (DLCO).
MATERIALS AND METHODSA total of 143 participants in the Multiethnic Study of Atherosclerosis COPD Study were examined by dynamic contrast-enhanced pulmonary perfusion magnetic resonance imaging (MRI) at 1.5 T. Pulmonary microvascular blood flow (PBF) was calculated on a pixel-by-pixel basis by using a dual-bolus technique and the Fermi function model. Semiquantitative parameters for regional pulmonary microvascular perfusion were calculated from signal intensity-time curves in the lung parenchyma. Intraoberserver and interobserver coefficients of variation (CVs) and correlations between quantitative and semiquantitative MRI parameters and with GLP and DLCO were determined.
RESULTSQuantitative and semiquantitative parameters of pulmonary microvascular perfusion were reproducible, with CVs for all parameters of less than 10%. Furthermore, these MRI parameters were correlated with GLP and DLCO, and there was good agreement between PBF and GLP. Quantitative and semiquantitative MRI parameters were closely correlated (eg, r = 0.86 for maximum signal increase with PBF). In participants without COPD, the physiological distribution of pulmonary perfusion could be determined by regional MRI measurements.
CONCLUSIONRegional pulmonary microvascular perfusion can reliably be quantified from dynamic contrast-enhanced MRI. Magnetic resonance imaging–derived quantitative and semiquantitative perfusion measures correlate with GLP and DLCO.
Details
- Title: Subtitle
- Quantitative and Semiquantitative Measures of Regional Pulmonary Microvascular Perfusion by Magnetic Resonance Imaging and Their Relationships to Global Lung Perfusion and Lung Diffusing Capacity: The Multiethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease Study
- Creators
- Katja Hueper - From the Johns Hopkins University, Baltimore, MD; †Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany; ‡Columbia University Medical Center, New York, NY; §Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD; ||Stanford University, Stanford, CA; ¶University of Iowa Carver College of Medicine, Iowa City, IA; #Washington University School of Medicine, St Louis, MOMegha ParikhMartin R PrinceChristian SchoenfeldChia LiuDavid BluemkeStephen DashnawThomas GoldsteinEric HoffmanJoao LimaJan SkrokJie ZhengR BarrJens Vogel-Claussen
- Resource Type
- Journal article
- Publication Details
- Investigative radiology, Vol.48(4), pp.223-230
- DOI
- 10.1097/RLI.0b013e318281057d
- PMID
- 23385398
- NLM abbreviation
- Invest Radiol
- ISSN
- 0020-9996
- eISSN
- 1536-0210
- Publisher
- Lippincott Williams & Wilkins, Inc
- Language
- English
- Date published
- 04/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051732502771
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