Journal article
Quantitative assessment of airway remodelling and response to allergen in asthma
Respirology (Carlton, Vic.), Vol.24(11), pp.1073-1080
11/2019
DOI: 10.1111/resp.13521
PMCID: PMC6732047
PMID: 30845351
Abstract
In vivo evaluation of the microstructural differences between asthmatic and non-asthmatic airways and their functional consequences is relevant to understanding and, potentially, treating asthma. In this study, we use endobronchial optical coherence tomography to investigate how allergic airways with asthma differ from allergic non-asthmatic airways in baseline microstructure and in response to allergen challenge.
A total of 45 subjects completed the study, including 20 allergic, mildly asthmatic individuals, 22 non-asthmatic allergic controls and 3 healthy controls. A 3-cm airway segment in the right middle and right upper lobe were imaged in each subject immediately before and 24 h following segmental allergen challenge to the right middle lobe. Relationships between optical airway measurements (epithelial and mucosal thicknesses, mucosal buckling and mucus) and airway obstruction (FEV
/FVC (forced expiratory volume in 1 s/forced vital capacity) and FEV
% (FEV
as a percentage of predictive value)) were investigated.
Significant increases at baseline and in response to allergen were observed for all four of our imaging metrics in the asthmatic airways compared to the non-asthmatic airways. Epithelial thickness and mucosal buckling exhibited a significant relationship to FEV
/FVC in the asthmatic group.
Simultaneous assessments of airway microstructure, buckling and mucus revealed both structural and functional differences between the mildly asthmatic and control groups, with airway buckling seeming to be the most relevant factor. The results of this study demonstrate that a comprehensive, microstructural approach to assessing the airways may be important in future asthma studies as well as in the monitoring and treatment of asthma.
Details
- Title: Subtitle
- Quantitative assessment of airway remodelling and response to allergen in asthma
- Creators
- David C Adams - Massachusetts General HospitalAlyssa J Miller - Massachusetts General HospitalMatthew B Applegate - Massachusetts General HospitalJosalyn L Cho - Massachusetts General HospitalDaniel L Hamilos - Massachusetts General HospitalAlex Chee - Massachusetts General HospitalJasmin A Holz - Massachusetts General HospitalMargit V Szabari - Massachusetts General HospitalLida P Hariri - Massachusetts General HospitalR Scott Harris - Massachusetts General HospitalJason W Griffith - Massachusetts General HospitalAndrew D Luster - Massachusetts General HospitalBenjamin D Medoff - Massachusetts General HospitalMelissa J Suter - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- Respirology (Carlton, Vic.), Vol.24(11), pp.1073-1080
- DOI
- 10.1111/resp.13521
- PMID
- 30845351
- PMCID
- PMC6732047
- ISSN
- 1323-7799
- eISSN
- 1440-1843
- Grant note
- U19 AI095261 / NIAID NIH HHS R01 HL133664 / NHLBI NIH HHS R37 AI040618 / NIAID NIH HHS R01 CA167827 / NCI NIH HHS
- Language
- English
- Date published
- 11/2019
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984359662502771
Metrics
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