Journal article
Quantitative assessment of chronic lung disease of infancy using computed tomography
The European respiratory journal, Vol.39(4), pp.992-999
04/2012
DOI: 10.1183/09031936.00064811
PMCID: PMC4332383
PMID: 22005925
Abstract
The aims of this study were to determine whether infants and toddlers with chronic lung disease of infancy (CLDI) have smaller airways and lower lung density compared with full-term healthy controls.
Multi-slice computed tomography (CT) chest scans were obtained at elevated lung volumes during a brief respiratory pause in sedated infants and toddlers; 38 CLDI were compared with 39 full-term controls. For CLDI subjects, gestational age at birth ranged from 25 to 29 weeks. Airway size was measured for the trachea and the next three to four generations into the right lower lobe; lung volumes and tissue density were also measured.
The relationship between airway size and airway generation differed between the CLDI and full-term groups; the sizes of the first and second airway generations were larger in the shorter CLDI than in the shorter full-term subjects. The increased size in the airways in the CLDI subjects was associated with increasing mechanical ventilation time in the neonatal period. CLDI subjects had a greater heterogeneity of lung density compared with full-term subjects.
Our results indicate that quantitative analysis of multi-slice CT scans at elevated volumes provides important insights into the pulmonary pathology of infants and toddlers with CLDI.
Details
- Title: Subtitle
- Quantitative assessment of chronic lung disease of infancy using computed tomography
- Creators
- E.E Sarria - Dept of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, INR Mattiello - Dept of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, INL Rao - Dept of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, INC.J Tiller - Dept of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, INB Poindexter - Dept of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, INK.E Applegate - Dept of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, INJ Granroth-Cook - Dept of Radiology, Iowa Children’s Hospital, Iowa City, IA, USAC Denski - Dept of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, INJ Nguyen - Division of Biostatistics, Indiana University School of Medicine, Indianapolis, INZ Yu - Division of Biostatistics, Indiana University School of Medicine, Indianapolis, INE Hoffman - Dept of Radiology, Iowa Children’s Hospital, Iowa City, IA, USAR.S Tepper - Dept of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN
- Resource Type
- Journal article
- Publication Details
- The European respiratory journal, Vol.39(4), pp.992-999
- DOI
- 10.1183/09031936.00064811
- PMID
- 22005925
- PMCID
- PMC4332383
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Language
- English
- Date published
- 04/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051752802771
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