Quantitative assessment of multiscale structural and functional alterations in asthmatic populations

Sanghun Choi; Eric A Hoffman; Sally E Wenzel; Mario Castro; Sean B Fain; Nizar N Jarjour; Mark L Schiebler; Kun Chen; Ching-Long Lin

doi:10.1152/japplphysiol.01094.2014

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Quantitative assessment of multiscale structural and functional alterations in asthmatic populations

Journal article

Open access

Peer reviewed

Quantitative assessment of multiscale structural and functional alterations in asthmatic populations

Sanghun Choi, Eric A Hoffman, Sally E Wenzel, Mario Castro, Sean B Fain, Nizar N Jarjour, Mark L Schiebler, Kun Chen and Ching-Long Lin

Journal of applied physiology (1985), Vol.118(10), pp.1286-1298

05/15/2015

DOI: 10.1152/japplphysiol.01094.2014

PMCID: PMC4436982

PMID: 25814641

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Abstract

Relationships between structural and functional variables in asthmatic lungs at local and global (or lobar) levels remain to be discovered. This study aims to investigate local alterations of structural variables [bifurcation angle, circularity, airway wall thickness (WT), and hydraulic diameter (Dh)] in asthmatic subjects, and their correlations with other imaging and pulmonary function test-based global and lobar metrics, including lung shape, air-trapping, regional volume change, and more. Sixty-one healthy subjects, and 67 nonsevere and 67 severe asthmatic subjects were studied. The structural variables were derived from computed tomography images at total lung capacity (TLC). Air-trapping was measured at functional residual capacity, and regional volume change (derived from image registration) was measured between functional residual capacity and TLC. The tracheal diameter and WT predicted by 61 healthy subjects were used to normalize the Dh and WT. New normalization schemes allowed for the dissociation of luminal narrowing and wall thickening effects. In severe asthmatic subjects, the alteration of bifurcation angle was found to be correlated with a global lung shape at TLC, and circularity was significantly decreased in the right main bronchus. While normalized WT increased especially in the upper lobes of severe asthmatic subjects, normalized Dh decreased in the lower lobes. Among local structural variables, normalized Dh was the most representative variable, because it was significantly correlated with alterations of functional variables, including pulmonary function test's data. In conclusion, understanding multiscale phenomena may help to provide guidance in the search for potential imaging-based phenotypes for the development and outcomes assessment of therapeutic intervention.

Lung - pathology

Asthma - physiopathology

Humans

Middle Aged

Bronchi - physiopathology

Male

Reference Values

Total Lung Capacity

Lung - physiopathology

Functional Residual Capacity

Forced Expiratory Volume

Trachea - pathology

Young Adult

Algorithms

Adult

Arteries - anatomy & histology

Female

Respiratory Function Tests

Trachea - physiopathology

Asthma - pathology

Bronchi - pathology

Details

Title: Subtitle: Quantitative assessment of multiscale structural and functional alterations in asthmatic populations
Creators: Sanghun Choi - Department of Mechanical and Industrial Engineering, University of Iowa, Iowa City, Iowa; IIHR-Hydroscience and Engineering, University of Iowa, Iowa City, Iowa
Eric A Hoffman - Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa; Department of Radiology, University of Iowa, Iowa City, Iowa; Department of Internal Medicine, University of Iowa, Iowa City, Iowa
Sally E Wenzel - Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
Mario Castro - Departments of Internal Medicine and Pediatrics, Washington University School of Medicine, St. Louis, Missouri
Sean B Fain - School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; and
Nizar N Jarjour - School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; and
Mark L Schiebler - School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; and
Kun Chen - Department of Statistics, University of Connecticut, Storrs, Connecticut
Ching-Long Lin - Department of Mechanical and Industrial Engineering, University of Iowa, Iowa City, Iowa; IIHR-Hydroscience and Engineering, University of Iowa, Iowa City, Iowa; ching-long-lin@uiowa.edu
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.118(10), pp.1286-1298
DOI: 10.1152/japplphysiol.01094.2014
PMID: 25814641
PMCID: PMC4436982
NLM abbreviation: J Appl Physiol (1985)
ISSN: 8750-7587
eISSN: 1522-1601
Publisher: United States
Grant note: U01 HL114494 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS U10 HL109257 / NHLBI NIH HHS HL-069116 / NHLBI NIH HHS S10 RR-022421 / NCRR NIH HHS HL-112986 / NHLBI NIH HHS HL-69174 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS HL-064368 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS U01 HL-114494 / NHLBI NIH HHS R01 HL-094315 / NHLBI NIH HHS
Language: English
Date published: 05/15/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Health, Sport, and Human Physiology ; Mechanical Engineering; Internal Medicine
Record Identifier: 9984051872902771

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