Journal article
Quantitative assessment of trabecular bone micro-architecture of the wrist via 7 Tesla MRI: preliminary results
Magma (New York, N.Y.), Vol.24(4), pp.191-199
05/05/2011
DOI: 10.1007/s10334-011-0252-0
PMCID: PMC3723135
PMID: 21544680
Abstract
Object
The goal of this study was to determine the feasibility of performing quantitative 7 T magnetic resonance imaging (MRI) assessment of trabecular bone micro-architecture of the wrist, a common fracture site.
Materials and methods
The wrists of 4 healthy subjects (1 woman, 3 men, 28±8.9 years) were scanned on a 7 T whole body MR scanner using a 3D fast low-angle shot (FLASH) sequence (TR/TE = 20/4.5 m s, 0.169×0.169×0.5 mm). Trabecular bone was segmented and divided into 4 or 8 angular subregions. Total bone volume (TBV), bone volume fraction (BVF), surface-curve ratio (SC), and erosion index (EI) were computed. Subjects were scanned twice to assess measurement reproducibility.
Results
Group mean subregional values for TBV, BVF, SC, and EI (8 subregion analysis) were as follows: 8489 ± 3686, 0.27 ± 0.045, 9.61 ± 6.52; and 1.43 ± 1.25. Within each individual, there was subregional variation in TBV, SC, and EI (>5%), but not BVF (<5%). Intersubject variation (≥12%) existed for all parameters. Within-subject coefficients of variation were ≤10%.
Conclusion
This is the first study to perform quantitative 7T MRI assessment of trabecular bone micro-architecture of the wrist. This method could be utilized to study perturbations in bone structure in subjects with osteoporosis or other bone disorders.
Details
- Title: Subtitle
- Quantitative assessment of trabecular bone micro-architecture of the wrist via 7 Tesla MRI: preliminary results
- Creators
- Gregory Chang - New York UniversityLigong Wang - New York UniversityGuoyuan Liang - University of IowaJames S Babb - New York UniversityGraham C Wiggins - New York UniversityPunam K Saha - University of IowaRavinder R Regatte - New York University
- Resource Type
- Journal article
- Publication Details
- Magma (New York, N.Y.), Vol.24(4), pp.191-199
- DOI
- 10.1007/s10334-011-0252-0
- PMID
- 21544680
- PMCID
- PMC3723135
- NLM abbreviation
- MAGMA
- ISSN
- 0968-5243
- eISSN
- 1352-8661
- Publisher
- Springer Berlin Heidelberg
- Language
- English
- Date published
- 05/05/2011
- Academic Unit
- Radiology; Electrical and Computer Engineering
- Record Identifier
- 9984197116902771
Metrics
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