Journal article
Quantitative cardiopulmonary magnetic resonance imaging in neonatal congenital diaphragmatic hernia
Pediatric radiology, Vol.52(12), pp.2306-2318
05/12/2022
DOI: 10.1007/s00247-022-05384-w
PMID: 35556152
Abstract
Pulmonary arterial hypertension, impaired cardiac function and lung hypoplasia are common in infants with congenital diaphragmatic hernia (CDH) and are associated with increased morbidity and mortality. Robust noninvasive methods to quantify these abnormalities in early infancy are lacking.
To determine the feasibility of MRI to quantify cardiopulmonary hemodynamics and function in infants with CDH and to investigate left-right blood flow and lung volume discrepancies.
We conducted a prospective MRI study of 23 neonates (isolated left CDH: 4 pre-repair, 7 post-repair, 3 pre- and post-repair; and 9 controls) performed on a small-footprint 1.5-tesla (T) scanner. We calculated MRI-based pulmonary arterial blood flow, left ventricular eccentricity index, cardiac function and lung volume. Using the Wilcoxon rank sum test for continuous data and Fisher exact test for categorical data, we made pairwise group comparisons.
The right-to-left ratios for pulmonary artery blood flow and lung volume were elevated in pre-repair and post-repair CDH versus controls (flow: P<0.005; volume: P<0.05 pre-/post-repair). Eccentricity index at end-systole significantly differed between pre-repair and post-repair CDH (P<0.01) and between pre-repair CDH and controls (P<0.001).
Cardiopulmonary MRI is a viable method to serially evaluate cardiopulmonary hemodynamics and function in critically ill infants and is useful for capturing left-right asymmetries in pulmonary blood flow and lung volume.
Details
- Title: Subtitle
- Quantitative cardiopulmonary magnetic resonance imaging in neonatal congenital diaphragmatic hernia
- Creators
- Jean A Tkach - Cincinnati Children's Hospital Medical CenterNara S Higano - Cincinnati Children's Hospital Medical CenterMichael D Taylor - Cincinnati Children's Hospital Medical CenterRyan A Moore - Cincinnati Children's Hospital Medical CenterMonir Hossain - Cincinnati Children's Hospital Medical CenterGuixia Huang - Cincinnati Children's Hospital Medical CenterDavid R Spielberg - Texas Children's HospitalSean B Fain - University of Wisconsin–MadisonPaul S Kingma - Cincinnati Children's Hospital Medical CenterJason C Woods - Cincinnati Children's Hospital Medical Center
- Resource Type
- Journal article
- Publication Details
- Pediatric radiology, Vol.52(12), pp.2306-2318
- DOI
- 10.1007/s00247-022-05384-w
- PMID
- 35556152
- ISSN
- 0301-0449
- eISSN
- 1432-1998
- Grant note
- R01 HL146689 / NIH HHS
- Language
- English
- Date published
- 05/12/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274955702771
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