Quantitative diffusion MRI using reduced field-of-view and multi-shot acquisition techniques: Validation in phantoms and prostate imaging

Yuxin Zhang; James Holmes; Iñaki Rabanillo; Arnaud Guidon; Shane Wells; Diego Hernando

doi:10.1016/j.mri.2018.04.006

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Quantitative diffusion MRI using reduced field-of-view and multi-shot acquisition techniques: Validation in phantoms and prostate imaging

Journal article

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Quantitative diffusion MRI using reduced field-of-view and multi-shot acquisition techniques: Validation in phantoms and prostate imaging

Yuxin Zhang, James Holmes, Iñaki Rabanillo, Arnaud Guidon, Shane Wells and Diego Hernando

Magnetic resonance imaging, Vol.51, pp.173-181

09/2018

DOI: 10.1016/j.mri.2018.04.006

PMCID: PMC6015549

PMID: 29678540

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Abstract

To evaluate the reproducibility of quantitative diffusion measurements obtained with reduced Field of View (rFOV) and Multi-shot EPI (msEPI) acquisitions, using single-shot EPI (ssEPI) as a reference. Diffusion phantom experiments, and prostate diffusion-weighted imaging in healthy volunteers and patients with known or suspected prostate cancer were performed across the three different sequences. Quantitative diffusion measurements of apparent diffusion coefficient, and diffusion kurtosis parameters (healthy volunteers), were obtained and compared across diffusion sequences (rFOV, msEPI, and ssEPI). Other possible confounding factors like b-value combinations and acquisition parameters were also investigated. Both msEPI and rFOV have shown reproducible quantitative diffusion measurements relative to ssEPI; no significant difference in ADC was observed across pulse sequences in the standard diffusion phantom (p = 0.156), healthy volunteers (p ≥ 0.12) or patients (p ≥ 0.26). The ADC values within the non-cancerous central gland and peripheral zone of patients were 1.29 ± 0.17 × 10−3 mm2/s and 1.74 ± 0.23 × 10−3 mm2/s respectively. However, differences in quantitative diffusion parameters were observed across different number of averages for rFOV, and across b-value groups and diffusion models for all the three sequences. Both rFOV and msEPI have the potential to provide high image quality with reproducible quantitative diffusion measurements in prostate diffusion MRI.

Multi-shot EPI

Prostate imaging

Quantitative diffusion MRI

Reduced field-of-view

Details

Title: Subtitle: Quantitative diffusion MRI using reduced field-of-view and multi-shot acquisition techniques: Validation in phantoms and prostate imaging
Creators: Yuxin Zhang - University of Wisconsin–Madison
James Holmes - University of Wisconsin–Madison
Iñaki Rabanillo - Universidad de Valladolid
Arnaud Guidon - Applications and Workflow, GE Healthcare, Boston, MA, United States.
Shane Wells - University of Wisconsin–Madison
Diego Hernando - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Magnetic resonance imaging, Vol.51, pp.173-181
DOI: 10.1016/j.mri.2018.04.006
PMID: 29678540
PMCID: PMC6015549
NLM abbreviation: Magn Reson Imaging
ISSN: 0730-725X
eISSN: 1873-5894
Publisher: Elsevier Inc
Language: English
Date published: 09/2018
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology
Record Identifier: 9984294926402771

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