Journal article
Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate
Magnetic resonance imaging, Vol.65, pp.100-108
01/01/2020
DOI: 10.1016/j.mri.2019.10.006
PMCID: PMC6956847
PMID: 31655139
Abstract
Objectives: To assess the feasibility of ferumoxytol-enhanced MRI in pregnancy with a nonhuman primate model.
Materials and methods: In this prospective study, eleven pregnant rhesus macaques at day 98 +/- 5 of gestation were divided into three groups, untreated control (UC) (n = 3), saline control (SC) (n = 4) and interleukin 1 beta (IL-1 beta) treated (IT) (n = 4), which were administered with either saline or IL-1 beta into the amniotic fluid. All animals were imaged at multiple time points before and after ferumoxytol administration (4 mg/kg). Longitudinal R2* and susceptibility of tissues were obtained using region-of-interest analysis and the longitudinal changes were assessed using linear mixed models and Student's t-test.
Results: In fetuses, a slope of 0.3 s(-1)/day (P = 0.008), 0.00 ppm/day (P = 0.699) and -0.2 s(-1)/day (P = 0.023) was observed in liver R2*, liver susceptibility, and lung R2*, respectively. In placentas, R2* and susceptibility increased immediately after ferumoxytol administration (P < 0.001) and decreased to baseline within two days. The mean change from baseline showed no significant difference between the SC group and the IT group at all scan time points. In maternal livers, R2* increased immediately after ferumoxytol administration, further increased at one-day, and then decreased but remained elevated (P < 0.001). The mean change from baseline showed no significant difference between the SC group and the IT group at all scan time points.
Conclusions: This work demonstrates the feasibility of quantitative ferumoxytol-enhanced MRI to measure dynamics of ferumoxytol delivery and washout in the placenta. Stable MRI measurements indicated no evidence of iron deposition in fetal tissues of nonhuman primates after maternal ferumoxytol exposure.
Details
- Title: Subtitle
- Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate
- Creators
- Ante Zhu - University of Wisconsin–MadisonScott B. Reeder - University of Wisconsin–MadisonKevin M. Johnson - University of Wisconsin–MadisonSydney M. Nguyen - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–MadisonIan M. Bird - University of Wisconsin–MadisonThaddeus G. Golos - University of Wisconsin–MadisonOliver Wieben - University of Wisconsin–MadisonDinesh M. Shah - University of Wisconsin–MadisonDiego Hernando - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance imaging, Vol.65, pp.100-108
- DOI
- 10.1016/j.mri.2019.10.006
- PMID
- 31655139
- PMCID
- PMC6956847
- NLM abbreviation
- Magn Reson Imaging
- ISSN
- 0730-725X
- eISSN
- 1873-5894
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- Wisconsin Alumni Research Foundation GE Healthcare; General Electric U01-HD087216; R01DK117354; R01-DK100651; K24-DK102595; P51 -0D011106 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 01/01/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984275053102771
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