Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner

Yi Su; Andrei G Vlassenko; Lars E Couture; Tammie L S Benzinger; Abraham Z Snyder; Colin P Derdeyn; Marcus E Raichle

doi:10.1177/0271678X16656200

Back

Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner

Journal article

Open access

Peer reviewed

Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner

Yi Su, Andrei G Vlassenko, Lars E Couture, Tammie L S Benzinger, Abraham Z Snyder, Colin P Derdeyn and Marcus E Raichle

Journal of cerebral blood flow and metabolism, Vol.37(4), pp.1435-1446

04/2017

DOI: 10.1177/0271678X16656200

PMCID: PMC5453463

PMID: 27401805

Files and links (1)

url

https://doi.org/10.1177/0271678X16656200View

Published (Version of record) Open Access

Abstract

Positron emission tomography (PET) with O-tracers is commonly used to measure brain hemodynamic parameters such as cerebral blood flow, cerebral blood volume, and cerebral metabolic rate of oxygen. Conventionally, the absolute quantification of these parameters requires an arterial input function that is obtained invasively by sampling blood from an artery. In this work, we developed and validated an image-derived arterial input function technique that avoids the unreliable and burdensome arterial sampling procedure for full quantitative O-PET imaging. We then compared hemodynamic PET imaging performed on a PET/MR hybrid scanner against a conventional PET only scanner. We demonstrated the proposed imaging-based technique was able to generate brain hemodynamic parameter measurements in strong agreement with the traditional arterial sampling based approach. We also demonstrated that quantitative O-PET imaging can be successfully implemented on a PET/MR hybrid scanner.

Brain - diagnostic imaging

Oxygen Radioisotopes

Cerebrovascular Circulation - physiology

Cerebral Arteries - diagnostic imaging

Humans

Middle Aged

Magnetic Resonance Imaging - methods

Male

Cerebral Arteries - physiology

Image Processing, Computer-Assisted - methods

Young Adult

Brain - blood supply

Adolescent

Cerebrovascular Disorders - diagnostic imaging

Adult

Female

Positron Emission Tomography Computed Tomography - methods

Details

Title: Subtitle: Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner
Creators: Yi Su - 1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, USA
Andrei G Vlassenko - 1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, USA
Lars E Couture - 1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, USA
Tammie L S Benzinger - 2 Department Neurosurgery, Washington University School of Medicine, USA
Abraham Z Snyder - 1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, USA
Colin P Derdeyn - 3 Department of Radiology, University of Iowa, USA
Marcus E Raichle - 4 Department of Neurology, Washington University School of Medicine, USA
Resource Type: Journal article
Publication Details: Journal of cerebral blood flow and metabolism, Vol.37(4), pp.1435-1446
Publisher: United States
DOI: 10.1177/0271678X16656200
PMID: 27401805
PMCID: PMC5453463
ISSN: 0271-678X
eISSN: 1559-7016
Grant note: P50 AG005681 / NIA NIH HHS UF1 AG032438 / NIA NIH HHS P01 AG003991 / NIA NIH HHS P01 NS080675 / NINDS NIH HHS P30 NS048056 / NINDS NIH HHS P01 AG026276 / NIA NIH HHS UL1 TR000448 / NCATS NIH HHS U19 AG032438 / NIA NIH HHS
Language: English
Date published: 04/2017
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020501202771

Metrics

22 Record Views

19 Times Cited - Web of Science

See more details