Quantitative measures of neurological function in chronic neuromuscular diseases and ataxia

Michael J Fillyaw; Gary J Badger; Walter G Bradley; Rup Tandan; Christiana J Blair; Timothy J Fries; David G Wilder; Joy Boerman; Jeffrey Young; Meijanti Witarsa

doi:10.1016/0022-510X(89)90172-X

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Quantitative measures of neurological function in chronic neuromuscular diseases and ataxia

Journal article

Peer reviewed

Quantitative measures of neurological function in chronic neuromuscular diseases and ataxia

Michael J Fillyaw, Gary J Badger, Walter G Bradley, Rup Tandan, Christiana J Blair, Timothy J Fries, David G Wilder, Joy Boerman, Jeffrey Young and Meijanti Witarsa

Journal of the neurological sciences, Vol.92(1), pp.17-36

1989

DOI: 10.1016/0022-510X(89)90172-X

PMID: 2769302

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Abstract

Interexaminer and intraexaminer reliability were determined for 30 quantitative measures of neurological function, including sensory threshold, tendon reflexes, maximum isometric strength, and timed tests and coded ratings of functional ability, in patients with Charcot-Marie-Tooth disease (n = 30), idiopathic polyneuropathy (n = 16) and spinocerebellar degeneration (n = 30). Five of 6 sensory and reflex measures had interexaminer reliability greater than 0.80 when the neurologists' examinations were 1 h apart; 2 of 7 achieved this level when the examinations were separated by 1 month. Interexaminer reliability between physical therapists was greater than 0.80 for 19 of 20 measures of strength and functional ability. Intraexaminer reliability coefficients greater than 0.80 were found for 13 of 24 sensory and reflex measures, 28 of 30 isometric strength measures, 24 of 30 timed tests and 5 of 6 coded ratings of functional ability. Electro-oculography, oral diadochokinetic syllable rates, hand and foot accelerometry, and tracings of sine and square waves were examined as quantitative indices of ataxia for patients with spinocerebellar degeneration. Of 11 measures of ataxia, only the oral diadochokinetic syllable rate test had acceptable reliability.

Ataxia

Neuromuscular disease

Neurological function

Reliability

Quantitative measures

Details

Title: Subtitle: Quantitative measures of neurological function in chronic neuromuscular diseases and ataxia
Creators: Michael J Fillyaw - Department of Neurology, University of Vermont, Burlington, VT U.S.A
Gary J Badger - Department of Medical Biostatistics, University of Vermont, Burlington, VT U.S.A
Walter G Bradley - Department of Neurology, University of Vermont, Burlington, VT U.S.A
Rup Tandan - Department of Neurology, University of Vermont, Burlington, VT U.S.A
Christiana J Blair - Department of Medical Biostatistics, University of Vermont, Burlington, VT U.S.A
Timothy J Fries - Department of Neurology, University of Vermont, Burlington, VT U.S.A
David G Wilder - Department of Orthopaedics and Rehabilitation, University of Vermont, Burlington, VT U.S.A
Joy Boerman - Department of Physical Therapy, University of Vermont, Burlington, VT U.S.A
Jeffrey Young - Department of Medical Biostatistics, University of Vermont, Burlington, VT U.S.A
Meijanti Witarsa - Department of Neurology, University of Vermont, Burlington, VT U.S.A
Resource Type: Journal article
Publication Details: Journal of the neurological sciences, Vol.92(1), pp.17-36
Publisher: Elsevier B.V
DOI: 10.1016/0022-510X(89)90172-X
PMID: 2769302
ISSN: 0022-510X
eISSN: 1878-5883
Language: English
Date published: 1989
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Occupational and Environmental Health
Record Identifier: 9984064231402771

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