Journal article
Quantitative muscle MRI as a sensitive marker of early muscle pathology in myotonic dystrophy type 1
Muscle & nerve, Vol.63(4), pp.553-562
04/2021
DOI: 10.1002/mus.27174
PMCID: PMC8442354
PMID: 33462896
Abstract
Quantitative muscle MRI as a sensitive marker of early muscle pathology and disease progression in adult-onset myotonic dystrophy type 1. The utility of muscle MRI as a marker of muscle pathology and disease progression in adult-onset myotonic dystrophy type 1 (DM1) was evaluated.
This prospective, longitudinal study included 67 observations from 36 DM1 patients (50% female), and 92 observations from 49 healthy adults (49% female). Lower-leg 3T magnetic resonance imaging (MRI) scans were acquired. Volume and fat fraction (FF) were estimated using a three-point Dixon method, and T2-relaxometry was determined using a multi-echo spin-echo sequence. Muscles were segmented automatically. Mixed linear models were conducted to determine group differences across muscles and image modality, accounting for age, sex, and repeated observations. Differences in rate of change in volume, T2-relaxometry, and FF were also determined with mixed linear regression that included a group by elapsed time interaction.
Compared with healthy adults, DM1 patients exhibited reduced volume of the tibialis anterior, soleus, and gastrocnemius (GAS) (all, P < .05). T2-relaxometry and FF were increased across all calf muscles in DM1 compared to controls. (all, P < .01). Signs of muscle pathology, including reduced volume, and increased T2-relaxometry and FF were already noted in DM1 patients who did not exhibit clinical motor symptoms of DM1. As a group, DM1 patients exhibited a more rapid change than did controls in tibialis posterior volume (P = .05) and GAS T2-relaxometry (P = .03) and FF (P = .06).
Muscle MRI renders sensitive, early markers of muscle pathology and disease progression in DM1. T2 relaxometry may be particularly sensitive to early muscle changes related to DM1.
Details
- Title: Subtitle
- Quantitative muscle MRI as a sensitive marker of early muscle pathology in myotonic dystrophy type 1
- Creators
- Ellen van der Plas - Department of Psychiatry, University of Iowa Hospital & Clinics, Iowa City, Iowa, USALaurie Gutmann - Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USADan Thedens - Department of Radiology, University of Iowa Hospital & Clinics, Iowa City, Iowa, USARichard K Shields - Department of Physical Therapy and Rehabilitation Science, University of Iowa Hospital & Clinics, Iowa City, Iowa, USAKathleen Langbehn - Department of Psychiatry, University of Iowa Hospital & Clinics, Iowa City, Iowa, USAZhihui Guo - Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, Iowa, USAMilan Sonka - Iowa Institute for Biomedical Imaging, University of Iowa, Iowa City, Iowa, USAPeggy Nopoulos - Department of Psychiatry, University of Iowa Hospital & Clinics, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Muscle & nerve, Vol.63(4), pp.553-562
- DOI
- 10.1002/mus.27174
- PMID
- 33462896
- PMCID
- PMC8442354
- NLM abbreviation
- Muscle Nerve
- ISSN
- 0148-639X
- eISSN
- 1097-4598
- Publisher
- United States
- Grant note
- S10 OD025025 / NIH HHS R01 NS094387 / NINDS NIH HHS
- Language
- English
- Date published
- 04/2021
- Academic Unit
- Neurology; Electrical and Computer Engineering; Psychiatry; Injury Prevention Research Center; Roy J. Carver Department of Biomedical Engineering; Radiology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Orthopedics and Rehabilitation; Radiation Oncology; Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984070888202771
Metrics
28 Record Views