Quantitative redox biology: an approach to understand the role of reactive species in defining the cellular redox environment

Garry R Buettner; Brett A Wagner; Victor G J Rodgers

doi:10.1007/s12013-011-9320-3

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Quantitative redox biology: an approach to understand the role of reactive species in defining the cellular redox environment

Journal article

Open access

Peer reviewed

Quantitative redox biology: an approach to understand the role of reactive species in defining the cellular redox environment

Garry R Buettner, Brett A Wagner and Victor G J Rodgers

Cell biochemistry and biophysics, Vol.67(2), pp.477-483

11/2013

DOI: 10.1007/s12013-011-9320-3

PMCID: PMC3661692

PMID: 22161621

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Abstract

Systems biology is now recognized as a needed approach to understand the dynamics of inter- and intra-cellular processes. Redox processes are at the foundation of nearly all aspects of biology. Free radicals, related oxidants, and antioxidants are central to the basic functioning of cells and tissues. They set the cellular redox environment and, therefore, are the key to regulation of biochemical pathways and networks, thereby influencing organism health. To understand how short-lived, quasi-stable species, such as superoxide, hydrogen peroxide, and nitric oxide, connect to the metabolome, proteome, lipidome, and genome we need absolute quantitative information on all redox active compounds as well as thermodynamic and kinetic information on their reactions, i.e., knowledge of the complete redoxome. Central to the state of the redoxome are the interactive details of the superoxide/peroxide formation and removal systems. Quantitative information is essential to establish the dynamic mathematical models needed to reveal the temporal evolution of biochemical pathways and networks. This new field of Quantitative Redox Biology will allow researchers to identify new targets for intervention to advance our efforts to achieve optimal human health.

Reactive Oxygen Species - metabolism

Oxidation-Reduction

Reactive Nitrogen Species - metabolism

Antioxidants - metabolism

Humans

Drug Discovery

Toxicity Tests

Details

Title: Subtitle: Quantitative redox biology: an approach to understand the role of reactive species in defining the cellular redox environment
Creators: Garry R Buettner - Free Radical and Radiation Biology & ESR Facility, Med Labs B180, The University of Iowa, Iowa City, IA, 52242-1181, USA, garry-buettner@uiowa.edu
Brett A Wagner
Victor G J Rodgers
Resource Type: Journal article
Publication Details: Cell biochemistry and biophysics, Vol.67(2), pp.477-483
DOI: 10.1007/s12013-011-9320-3
PMID: 22161621
PMCID: PMC3661692
NLM abbreviation: Cell Biochem Biophys
ISSN: 1085-9195
eISSN: 1559-0283
Publisher: United States
Grant note: R01GM073929 / NIGMS NIH HHS P30 ES005605 / NIEHS NIH HHS R01 GM073929 / NIGMS NIH HHS P42 ES013661 / NIEHS NIH HHS P42ES013661 / NIEHS NIH HHS
Language: English
Date published: 11/2013
Academic Unit: Radiation Oncology
Record Identifier: 9984047632602771

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