Quantitative trait loci affecting the difference in pigmentation between Drosophila yakuba and D. santomea

Mary Anna Carbone; Ana Llopart; Matthew deAngelis; Jerry A Coyne; Trudy F C Mackay

doi:10.1534/genetics.105.044412

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Quantitative trait loci affecting the difference in pigmentation between Drosophila yakuba and D. santomea

Journal article

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Quantitative trait loci affecting the difference in pigmentation between Drosophila yakuba and D. santomea

Mary Anna Carbone, Ana Llopart, Matthew deAngelis, Jerry A Coyne and Trudy F C Mackay

Genetics (Austin), Vol.171(1), pp.211-225

09/2005

DOI: 10.1534/genetics.105.044412

PMCID: PMC1456512

PMID: 15972457

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Abstract

Using quantitative trait locus (QTL) mapping, we studied the genetic basis of the difference in pigmentation between two sister species of Drosophila: Drosophila yakuba, which, like other members of the D. melanogaster subgroup, shows heavy black pigmentation on the abdomen of males and females, and D. santomea, an endemic to the African island of São Tomé, which has virtually no pigmentation. Here we mapped four QTL with large effects on this interspecific difference in pigmentation: two on the X chromosome and one each on the second and third chromosomes. The same four QTL were detected in male hybrids in the backcrosses to both D. santomea and D. yakuba and in the female D. yakuba backcross hybrids. All four QTL exhibited strong epistatic interactions in male backcross hybrids, but only one pair of QTL interacted in females from the backcross to D. yabuka. All QTL from each species affected pigmentation in the same direction, consistent with adaptive evolution driven by directional natural selection. The regions delimited by the QTL included many positional candidate loci in the pigmentation pathway, including genes affecting catecholamine biosynthesis, melanization of the cuticle, and many additional pleiotropic effects.

Haplotypes

Genes, Insect - genetics

Species Specificity

Genotype

Male

Chromosome Mapping

Skin Pigmentation - genetics

Genetic Variation

Animals

Epistasis, Genetic

Hybridization, Genetic

Female

Crosses, Genetic

Quantitative Trait Loci - genetics

Details

Title: Subtitle: Quantitative trait loci affecting the difference in pigmentation between Drosophila yakuba and D. santomea
Creators: Mary Anna Carbone - Department of Genetics, North Carolina State University, Raleigh 27695, USA. macarbon@unity.ncsu.edu
Ana Llopart
Matthew deAngelis
Jerry A Coyne
Trudy F C Mackay
Resource Type: Journal article
Publication Details: Genetics (Austin), Vol.171(1), pp.211-225
DOI: 10.1534/genetics.105.044412
PMID: 15972457
PMCID: PMC1456512
NLM abbreviation: Genetics
ISSN: 0016-6731
eISSN: 1943-2631
Publisher: United States
Grant note: P01 GM045344 / NIGMS NIH HHS GM45344 / NIGMS NIH HHS GM 58260 / NIGMS NIH HHS R01 GM058260 / NIGMS NIH HHS
Language: English
Date published: 09/2005
Academic Unit: Biology
Record Identifier: 9983991998202771

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