Quantitative trait loci analysis of human event-related brain potentials: P3 voltage

H Begleiter; B Porjesz; T Reich; H.J Edenberg; A Goate; J Blangero; L Almasy; T Foroud; P Van Eerdewegh; J Polich; J Rohrbaugh; S Kuperman; L.O Bauer; S.J O'Connor; D.B Chorlian; T.K Li; P.M Conneally; V Hesselbrock; J.P Rice; M.A Schuckit; R Cloninger; J Nurnberger; R Crowe; F.E Bloom

doi:10.1016/S0168-5597(98)00002-1

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Journal article

Quantitative trait loci analysis of human event-related brain potentials: P3 voltage

H Begleiter, B Porjesz, T Reich, H.J Edenberg, A Goate, J Blangero, L Almasy, T Foroud, P Van Eerdewegh, J Polich, …

Electroencephalography and clinical neurophysiology / Evoked potentials section, Vol.108(3), pp.244-250

1998

DOI: 10.1016/S0168-5597(98)00002-1

PMID: 9607513

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Abstract

The P3 event-related brain potential (ERP) is a positive-going voltage change of scalp-recorded electroencephalographic activity that occurs between 300–500 ms after stimulus onset. It is elicited when a stimulus is perceived, memory operations are engaged, and attentional resources are allocated toward its processing. Because this ERP component reflects fundamental cognitive processing, it has found wide utility as an assessment of human mental function in basic and clinical studies. In particular, P3 attributes are heritable and have demonstrated considerable promise as a means to identify individuals at genetic risk for alcoholism. We have conducted a quantitative linkage analysis on a large sample from families with a high density of affected individuals. The analyses suggest that several regions of the human genome contain genetic loci related to the generation of the P3 component of the ERP, which are possible candidate loci underlying the functional organization of human neuroelectric activity.

Quantitative trait loci

Event-related brain potentials

Heredity

Alcoholism

Details

Title: Subtitle: Quantitative trait loci analysis of human event-related brain potentials: P3 voltage
Creators: H Begleiter - Department of Psychiatry, SUNY Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
B Porjesz - Department of Psychiatry, SUNY Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
T Reich - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
H.J Edenberg - Indiana University School of Medicine, Indianapolis, IN 46202, USA
A Goate - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
J Blangero - Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
L Almasy - Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
T Foroud - Indiana University School of Medicine, Indianapolis, IN 46202, USA
P Van Eerdewegh - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
J Polich - Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Rohrbaugh - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
S Kuperman - Department of Psychiatric Research, University of Iowa, Iowa City, IA 52242, USA
L.O Bauer - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
S.J O'Connor - Indiana University School of Medicine, Indianapolis, IN 46202, USA
D.B Chorlian - Department of Psychiatry, SUNY Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
T.K Li - Indiana University School of Medicine, Indianapolis, IN 46202, USA
P.M Conneally - Indiana University School of Medicine, Indianapolis, IN 46202, USA
V Hesselbrock - Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USA
J.P Rice - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
M.A Schuckit - Department of Psychiatry, University of California, San Diego, San Diego, CA 92161, USA
R Cloninger - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
J Nurnberger - Indiana University School of Medicine, Indianapolis, IN 46202, USA
R Crowe - Department of Psychiatric Research, University of Iowa, Iowa City, IA 52242, USA
F.E Bloom - Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Resource Type: Journal article
Publication Details: Electroencephalography and clinical neurophysiology / Evoked potentials section, Vol.108(3), pp.244-250
DOI: 10.1016/S0168-5597(98)00002-1
PMID: 9607513
NLM abbreviation: Electroencephalogr Clin Neurophysiol
ISSN: 0168-5597
eISSN: 1872-6380
Publisher: Elsevier Ireland Ltd
Language: English
Date published: 1998
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984003943402771

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