Quantitative-trait-locus mapping in the presence of locus heterogeneity

K Wang; Y Peng

doi:10.1111/j.1469-1809.2006.00277.x

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Quantitative-trait-locus mapping in the presence of locus heterogeneity

Journal article

Peer reviewed

Quantitative-trait-locus mapping in the presence of locus heterogeneity

K Wang and Y Peng

Annals of human genetics, Vol.70(Pt 6), pp.882-892

11/2006

DOI: 10.1111/j.1469-1809.2006.00277.x

PMID: 17044863

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Abstract

Locus heterogeneity is a concern for quantitative trait locus mapping where phenotypes are likely to be influenced by more than one gene. We introduce a model which generalizes the locus heterogeneity model of Smith (1961) from dichotomous traits to quantitative traits and consider some test statistics for this model. The type I error rates and the power of these statistics are assessed through simulation studies. These statistics are applied to a linkage study of asthma genes.

Computer Simulation

Humans

Chromosome Mapping

Models, Statistical

Quantitative Trait Loci

Asthma - genetics

Genetic Heterogeneity

Genetic Linkage

Details

Title: Subtitle: Quantitative-trait-locus mapping in the presence of locus heterogeneity
Creators: K Wang - Program in Public Health Genetics, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA. kai-wang@uiowa.edu
Y Peng
Resource Type: Journal article
Publication Details: Annals of human genetics, Vol.70(Pt 6), pp.882-892
DOI: 10.1111/j.1469-1809.2006.00277.x
PMID: 17044863
NLM abbreviation: Ann Hum Genet
ISSN: 0003-4800
eISSN: 1469-1809
Publisher: England
Language: English
Date published: 11/2006
Academic Unit: Biostatistics
Record Identifier: 9983997339202771

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