Quantra™ should be considered a tool for two-grade scale mammographic breast density classification

Ernest U Ekpo; Mark F McEntee; Mary Rickard; Patrick C Brennan; Jyotsna Kunduri; Delgermaa Demchig; Claudia Mello-Thoms

doi:10.1259/bjr.20151057

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Quantra™ should be considered a tool for two-grade scale mammographic breast density classification

Journal article

Open access

Peer reviewed

Quantra™ should be considered a tool for two-grade scale mammographic breast density classification

Ernest U Ekpo, Mark F McEntee, Mary Rickard, Patrick C Brennan, Jyotsna Kunduri, Delgermaa Demchig and Claudia Mello-Thoms

British journal of radiology, Vol.89(1060), pp.20151057-20151057

2016

DOI: 10.1259/bjr.20151057

PMCID: PMC4846223

PMID: 26882045

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Abstract

To assess the agreement between Quantra™ (Hologic Inc., Bedford, MA) and Breast Imaging Reporting and Data Systems (BI-RADS(®)) and the performance of Quantra at reproducing BI-RADS mammographic breast density (MBD) assessment. MBD assessment was performed using Quantra and BI-RADS. BI-RADS assessment was performed in two phases (1314 and 292 cases, respectively). Kappa was used to assess the interreader agreement and the agreement between Quantra and BI-RADS, and receiver-operating characteristics analysis was used to assess the performance of Quantra at reproducing BI-RADS rating. Agreement (weighted kappa) between BI-RADS and Quantra in Phase 1 was 0.75 [95% confidence interval (CI): 0.73-0.78] and 0.85 (95% CI: 0.80-0.90) on four- and two-grade scales, respectively. The corresponding agreement in Phase 2 was 0.79 (95% CI: 0.75-0.84) and 0.84 (95% CI: 0.79-0.87) using the majority report. In Phase 1, Quantra demonstrated 93.2% sensitivity and 86.1% specificity for BI-RADS on a two-grade scale (1-2 vs 3-4). In Phase 2, it demonstrated 91.3% sensitivity and 83.6% specificity on a two-grade scale. Quantra is limited in reproducing BI-RADS rating on a four-grade scale; however, it highly reproduces BI-RADS assessment on a two-grade scale. Quantra (v. 2.0) is a poor predictor of BI-RADS assessment on a four-grade scale, but well reproduces BI-RADS rating on a two-grade scale. Therefore, it should be considered a tool for two-grade scale MBD classification.

Radiographic Image Interpretation, Computer-Assisted - methods

Breast Neoplasms - pathology

Humans

Sensitivity and Specificity

Organ Size

Female

Breast Neoplasms - diagnostic imaging

Mammography - methods

Breast - pathology

Details

Title: Subtitle: Quantra™ should be considered a tool for two-grade scale mammographic breast density classification
Creators: Ernest U Ekpo - 2 Department of Radiography and Radiology, University of Calabar, Calabar, Nigeria
Mark F McEntee - 1 Discipline of Medical Radiation Sciences in the Faculty of Health Sciences and the Brain and Mind Research Institute, The University of Sydney, Australia
Mary Rickard - 3 Sydney Breast Clinic, Sydney, NSW, Australia
Patrick C Brennan - 1 Discipline of Medical Radiation Sciences in the Faculty of Health Sciences and the Brain and Mind Research Institute, The University of Sydney, Australia
Jyotsna Kunduri - 3 Sydney Breast Clinic, Sydney, NSW, Australia
Delgermaa Demchig - 1 Discipline of Medical Radiation Sciences in the Faculty of Health Sciences and the Brain and Mind Research Institute, The University of Sydney, Australia
Claudia Mello-Thoms - 1 Discipline of Medical Radiation Sciences in the Faculty of Health Sciences and the Brain and Mind Research Institute, The University of Sydney, Australia
Resource Type: Journal article
Publication Details: British journal of radiology, Vol.89(1060), pp.20151057-20151057
DOI: 10.1259/bjr.20151057
PMID: 26882045
PMCID: PMC4846223
NLM abbreviation: Br J Radiol
ISSN: 0007-1285
eISSN: 1748-880X
Publisher: England
Language: English
Date published: 2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology
Record Identifier: 9984051590502771

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