Quantum chemical insight into the effects of the local electron environment on T-2-based MRI

M. S. Petronek; J. J. St-Aubin; C. Y. Lee; D. R. Spitz; E. G. Gillan; B. G. Allen; V. A. Magnotta

doi:10.1038/s41598-021-00305-7

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Quantum chemical insight into the effects of the local electron environment on T-2-based MRI

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Quantum chemical insight into the effects of the local electron environment on T-2-based MRI

M. S. Petronek, J. J. St-Aubin, C. Y. Lee, D. R. Spitz, E. G. Gillan, B. G. Allen and V. A. Magnotta

Scientific reports, Vol.11(1), p.20817

10/21/2021

DOI: 10.1038/s41598-021-00305-7

PMCID: PMC8531323

PMID: 34675308

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Abstract

T-2* relaxation is an intrinsic magnetic resonance imaging (MRI) parameter that is sensitive to local magnetic field inhomogeneities created by the deposition of endogenous paramagnetic material (e.g. iron). Recent studies suggest that T-2* mapping is sensitive to iron oxidation state. In this study, we evaluate the spin state-dependence of T-2* relaxation using T-2* mapping. We experimentally tested this physical principle using a series of phantom experiments showing that T-2* relaxation times are directly proportional to the spin magnetic moment of different transition metals along with their associated magnetic susceptibility. We previously showed that T-2* relaxation time can detect the oxidation of Fe2+. In this paper, we demonstrate that T-2* relaxation times are significantly longer for the diamagnetic, d(10) metal Ga3+, compared to the paramagnetic, d(5) metal Fe3+. We also show in a cell culture model that cells supplemented with Ga3+ (S = 0) have a significantly longer relaxation time compared to cells supplemented with Fe3+ (S = 5/2). These data support the hypothesis that dipole-dipole interactions between protons and electrons are driven by the strength of the electron spin magnetic moment in the surrounding environment giving rise to T-2* relaxation.

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Details

Title: Subtitle: Quantum chemical insight into the effects of the local electron environment on T-2-based MRI
Creators: M. S. Petronek - University of Iowa
J. J. St-Aubin - University of Iowa
C. Y. Lee - University of Iowa
D. R. Spitz - University of Iowa
E. G. Gillan - University of Iowa
B. G. Allen - University of Iowa
V. A. Magnotta - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Scientific reports, Vol.11(1), p.20817
DOI: 10.1038/s41598-021-00305-7
PMID: 34675308
PMCID: PMC8531323
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Publisher: NATURE PORTFOLIO
Number of pages: 7
Grant note: Carver College of Medicine T32 CA078586; P01 CA217797; P01 CA244091; R01 CA169046; R21 CA256301 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30 CA086862 / Holden Comprehensive Cancer Center, NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA G-17-1500 / Gateway for Cancer Research
Language: English
Date published: 10/21/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Chemistry
Record Identifier: 9984312983502771

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