Journal article
Quercetin Inhibits Diethylnitrosamine-Induced Hepatic Preneoplastic Lesions in Rats
Nutrition and cancer, Vol.63(2), pp.234-241
01/01/2011
DOI: 10.1080/01635581.2011.523806
PMID: 21302176
Abstract
Quercetin is an antioxidant flavonoid, found ubiquitously in nature and extensively used in herbal medicines and food additives. This study aimed to investigate the effect of quercetin on diethylnitrosamine-induced preneoplastic lesions, using the medium-term rat liver bioassay. The -benzene hexachloride was used as promoter at the doses of 0.1, 1.0, and 10.0 mg/kg against a single dose of diethylnitrosamine (200 mg/kg) in male Sprague-Dawley rats. All the rats were subjected to 70% partial hepatectomy at Week 4. The protective effect of quercetin (5 and 25 mg/kg) was examined against the highest dose of -benzene hexachloride (10 mg/kg). A significant increase in the number as well as the mean area of glutathione S-transferase placental form (GST-P) positive foci, p53 positive hepatocytes, and the percentage of apoptotic cells were observed in the diethylnitrosamine-treated group. In the present investigation, both doses of QC (5 and 25 mg/kg) led to a significant decrease in the number as well as the mean area of GST-P positive foci, TUNEL positive apoptotic cells, p53 positive hepatocytes, and restoration of cellular morphology. These results clearly indicate that quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in medium-term rat liver bioassay.
Details
- Title: Subtitle
- Quercetin Inhibits Diethylnitrosamine-Induced Hepatic Preneoplastic Lesions in Rats
- Creators
- C. Gupta - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research , Punjab, IndiaD. N. Tripathi - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research , Punjab, IndiaA. Vikram - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research , Punjab, IndiaP. Ramarao - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research , Punjab, IndiaG. B. Jena - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research , Punjab, India
- Resource Type
- Journal article
- Publication Details
- Nutrition and cancer, Vol.63(2), pp.234-241
- Publisher
- Taylor & Francis
- DOI
- 10.1080/01635581.2011.523806
- PMID
- 21302176
- ISSN
- 0163-5581
- eISSN
- 1532-7914
- Number of pages
- 8
- Grant note
- National Institute of Pharmaceutical Education and Research (NIPER), Mohali 111172/2K8/1 / CSIR; Council of Scientific & Industrial Research (CSIR) - India
- Language
- English
- Date published
- 01/01/2011
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984359923902771
Metrics
5 Record Views