Quercitrin protects skin from UVB-induced oxidative damage

Yuanqin Yin; Wenqi Li; Young-Ok Son; Lijuan Sun; Jian Lu; Donghern Kim; Xin Wang; Hua Yao; Lei Wang; Poyil Pratheeshkumar; Andrew J Hitron; Jia Luo; Ning Gao; Xianglin Shi; Zhuo Zhang

doi:10.1016/j.taap.2013.03.015

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Quercitrin protects skin from UVB-induced oxidative damage

Journal article

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Peer reviewed

Quercitrin protects skin from UVB-induced oxidative damage

Yuanqin Yin, Wenqi Li, Young-Ok Son, Lijuan Sun, Jian Lu, Donghern Kim, Xin Wang, Hua Yao, Lei Wang, Poyil Pratheeshkumar, …

Toxicology and applied pharmacology, Vol.269(2), pp.89-99

06/01/2013

DOI: 10.1016/j.taap.2013.03.015

PMCID: PMC3700335

PMID: 23545178

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Abstract

Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin. •Oxidative stress plays a key role in UV-induced cell and tissue injuries.•Quercitrin decreases ROS generation and restores antioxidants irradiated by UVB.•Quercitrin reduces UVB-irradiated oxidative DNA damage, apoptosis, and inflammation.•Quercitrin functions as an antioxidant against UVB-induced skin injuries.

Antioxidant

Apoptosis

Inflammation

Oxidative damage

Quercitrin

Ultraviolet B

Details

Title: Subtitle: Quercitrin protects skin from UVB-induced oxidative damage
Creators: Yuanqin Yin - China Medical University (PRC)
Wenqi Li - University of Kentucky
Young-Ok Son - University of Kentucky
Lijuan Sun - University of Kentucky
Jian Lu - University of Kentucky
Donghern Kim - University of Kentucky
Xin Wang - University of Kentucky
Hua Yao - Zhejiang University
Lei Wang - University of Kentucky
Poyil Pratheeshkumar - University of Kentucky
Andrew J Hitron - University of Kentucky
Jia Luo - University of Kentucky
Ning Gao - Department of Pharmacognos, College of Pharmacy, 3rd Military Medical University, Chongqing, China
Xianglin Shi - University of Kentucky
Zhuo Zhang - University of Kentucky
Resource Type: Journal article
Publication Details: Toxicology and applied pharmacology, Vol.269(2), pp.89-99
DOI: 10.1016/j.taap.2013.03.015
PMID: 23545178
PMCID: PMC3700335
NLM abbreviation: Toxicol Appl Pharmacol
ISSN: 0041-008X
eISSN: 1096-0333
Publisher: Elsevier Inc
Language: English
Date published: 06/01/2013
Academic Unit: Pathology
Record Identifier: 9984201247002771

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