Journal article
Quinolinic acid in patients with systemic lupus erythematosus and neuropsychiatric manifestations
Journal of rheumatology, Vol.23(5), pp.850-855
1996
PMID: 8724297
Abstract
Objective. To evaluate the relationship between quinolinic acid, a neuroactive metabolite of L-tryptophan, and neuropsychiatric manifestations of systemic lupus erythematosus (SLE). Methods. Forty specimens of cerebrospinal fluid (CSF) were obtained from 39 patients with SLE who were evaluated for 40 episodes of neuropsychiatric dysfunction. The diagnosis of of neuropsychiatric dysfunction was determined clinically. CSF and serum specimens were analyzed for levels of quinolinic acid without knowledge of the clinical diagnosis. Results. Neuropsychiatric dysfunction attributed to SLE (NPSLE) was confirmed in 30 patient-episodes (Group 1), whereas in the other 10 (Group 2) other etiologies were felt to explain their CNS dysfunction. The median levels of CSF quinolinic acid for Group 1 (232.5 nmol/l) were significantly higher than those for Group 2 (median 38.2 nmol/l) (p < 0.014). CSF and serum quinolinic acid levels correlated significantly (p < 0.003) but there was no correlation between CSF quinolinic acid and CSF protein concentrations or white blood cell counts. Conclusion. We conclude that elevated quinolinic acid levels in the CSF and serum may be associated with NPSLE and could possibly play a role in its pathogenesi
Details
- Title: Subtitle
- Quinolinic acid in patients with systemic lupus erythematosus and neuropsychiatric manifestations
- Creators
- S. A VOGELGESANG - Rheumatology Services of Walter Reed Army Medical Center, Washington, DC, United StatesM. P HEYES - Rheumatology Services of Walter Reed Army Medical Center, Washington, DC, United StatesS. G WEST - Rheumatology Services of Walter Reed Army Medical Center, Washington, DC, United StatesA. M SALAZAR - Rheumatology Services of Walter Reed Army Medical Center, Washington, DC, United StatesP. P SFIKAKIS - Rheumatology Services of Walter Reed Army Medical Center, Washington, DC, United StatesR. N LIPNICK - Rheumatology Services of Walter Reed Army Medical Center, Washington, DC, United StatesG. L KLIPPLE - Rheumatology Services of Walter Reed Army Medical Center, Washington, DC, United StatesG. C TSOKOS - Rheumatology Services of Walter Reed Army Medical Center, Washington, DC, United States
- Resource Type
- Journal article
- Publication Details
- Journal of rheumatology, Vol.23(5), pp.850-855
- Publisher
- Journal of Rheumatology Publishing
- PMID
- 8724297
- ISSN
- 0315-162X
- eISSN
- 1499-2752
- Language
- English
- Date published
- 1996
- Academic Unit
- Immunology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984094755602771
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