Journal article
Quinolones do not interact with NMDA receptor in dissociated rat hippocampal neurons
Brain research, Vol.562(2), pp.344-346
1991
DOI: 10.1016/0006-8993(91)90645-C
PMID: 1837751
Abstract
Interaction of quinolone antimicrobials and fenbufen, anti-inflammatory agents, with the
N-methyl-
d-aspartate (NMDA) receptor was investigated in rat hippocampal neurons with the conventional patch-clamp technique. Simultaneous applications of quinolones and a metabolite of fenbufen had no effects on the glutamate- and NMDA-induced currents. The blocking effects of Mg
2+ and MK-801 on NMDA responses were also unaffected. Therefore, the convulsive action induced by quinolones and fenbulen does not seem to involve the functional change of NMDA receptor.
Details
- Title: Subtitle
- Quinolones do not interact with NMDA receptor in dissociated rat hippocampal neurons
- Creators
- Tetsuya ShirasakiNobutoshi HarataToshio NakayeNorio Akaike
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.562(2), pp.344-346
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(91)90645-C
- PMID
- 1837751
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Grant note
- DOI: 10.13039/501100001700, name: Ministry of Education, Culture, Sports, Science and Technology
- Language
- English
- Date published
- 1991
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984025559102771
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