Journal article
Quorum sensing in Staphylococcus infections
The Journal of clinical investigation, Vol.112(11), pp.1620-1625
12/01/2003
DOI: 10.1172/JCI20442
PMID: 14660735
Abstract
Quorum sensing via the accessory gene regulator (agr) system has been assigned a central role in the pathogenesis of staphylococci, particularly Staphylococcus aureus. While the control of virulence gene expression in vitro by agr has been relatively straightforward to describe, regulation of both the quorum response itself and virulence genes in vivo is considerably more complex. The quorum response is highly dependent upon the environment in which the organism is grown and is strongly influenced by additional regulators that respond to signals other than cell density. There is increasing evidence that the agr phenotype may influence the behavior and pathogenesis of biofilm-associated S. aureus and S. epidermidis and may contribute to the chronic nature of some biofilm-associated infections.
Details
- Title: Subtitle
- Quorum sensing in Staphylococcus infections
- Creators
- Jeremy M YarwoodPatrick M Schlievert
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.112(11), pp.1620-1625
- DOI
- 10.1172/JCI20442
- PMID
- 14660735
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 12/01/2003
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001218602771
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