Journal article
R-CHOP(-like) treatment of diffuse large B-cell lymphoma significantly reduces CT-assessed vertebral bone density: a single center study of 111 patients
Leukemia & lymphoma, Vol.58(5), pp.1105-1113
05/04/2017
DOI: 10.1080/10428194.2016.1233543
PMID: 27736260
Abstract
Treatment of diffuse large B-cell lymphoma (DLBCL) with R-CHOP(-like) regimens include large cumulative doses of prednisolone. In this retrospective study, we evaluated changes in vertebral bone density (VD) in DLBCL patients by measuring CT-ascertained Hounsfield units (HU) at the L3 level. In total, 111 patients diagnosed from 2007 to 2012 and response assessed following first line treatment were included. Post-treatment VD was significantly reduced to 86% of pretreatment VD on average (p < .001). Neither female sex nor high age (>70 years) were significantly associated with greater post-treatment VD reduction. Two years after completing R-CHOP treatment, VD remained significantly lower than baseline VD (p < .001). Vertebral compression fractures visualized by CT were found in 16/111 patients (14%) during follow-up. In conclusion, bone mineral density is significantly reduced following R-CHOP(-like) treatment and vertebral compression fractures are common. Glucocorticoid-induced osteoporosis may therefore have impact on survivorship for the large fraction of DLBCL patients with durable remissions.
Details
- Title: Subtitle
- R-CHOP(-like) treatment of diffuse large B-cell lymphoma significantly reduces CT-assessed vertebral bone density: a single center study of 111 patients
- Creators
- Pernille Svendsen - Aalborg University HospitalNitesh Shekhrajka - Aalborg University HospitalKasper Lindblad Nielsen - Aalborg University HospitalPeter Vestergaard - Aalborg University HospitalMette Østergaard Poulsen - Aalborg University HospitalAnders Krog Vistisen - Aalborg University HospitalPeter Svenssen Munksgaard - Aalborg University HospitalMarianne Tang Severinsen - Aalborg University HospitalPaw Jensen - Aalborg University HospitalHans Erik Johnsen - Aalborg University HospitalLasse Hjort Jakobsen - Aalborg University HospitalMartin Bøgsted - Aalborg University HospitalJens Brøndum Frøkjær - Aalborg University HospitalTarec Christoffer El-Galaly - Aalborg University Hospital
- Resource Type
- Journal article
- Publication Details
- Leukemia & lymphoma, Vol.58(5), pp.1105-1113
- Publisher
- Taylor & Francis
- DOI
- 10.1080/10428194.2016.1233543
- PMID
- 27736260
- ISSN
- 1042-8194
- eISSN
- 1029-2403
- Grant note
- no grant number / North Denmark Region
- Language
- English
- Date published
- 05/04/2017
- Academic Unit
- Radiology
- Record Identifier
- 9984697731702771
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