REFINE: a database of linked clinical data and genomic biomarkers in renal cell carcinoma patients receiving immunotherapy-based treatment regimens

Jeffrey Zhong; Albert Jang; Bashar Abuqayas; Arnab Basu; David J Benjamin; Vineel Bhatlapenumarthi; Mehmet Asim Bilen; Dhvani Buch; Mark Chang; Erica Chin; Sourat Darabi; Nagendra Dhanikonda; Pooja Ghatalia; Claud M Grigg; Abby L Grier; Tanya Jindal; Joannah Jung; Deepak Kilari; Hamsa L S Kumar; Suzanna Lee; Brittany Neelands; Chinmayi Pandya; Jeff Pawalek; Jaimee Staggers; Ahmet Yildirim; Yousef Zakharia; Kevin K Zarrabi; Michael Zimmerman; George Sledge; David Spetzler; Andrew Elliott; Rana R McKay; Pedro C Barata

doi:10.1093/oncolo/oyaf135

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REFINE: a database of linked clinical data and genomic biomarkers in renal cell carcinoma patients receiving immunotherapy-based treatment regimens

Journal article

Open access

Peer reviewed

REFINE: a database of linked clinical data and genomic biomarkers in renal cell carcinoma patients receiving immunotherapy-based treatment regimens

Jeffrey Zhong, Albert Jang, Bashar Abuqayas, Arnab Basu, David J Benjamin, Vineel Bhatlapenumarthi, Mehmet Asim Bilen, Dhvani Buch, Mark Chang, Erica Chin, …

The oncologist (Dayton, Ohio), Vol.30(6), oyaf135

06/04/2025

DOI: 10.1093/oncolo/oyaf135

PMCID: PMC12204391

PMID: 40536267

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Abstract

The REnal cancer consortium for Focused Investigation of Novel biomarkers and Expression (REFINE) consortium represents an important initiative in integrating clinical data with molecular sequencing in patients with advanced renal cell carcinoma (RCC) treated with immunotherapy-based approaches. By leveraging real-world evidence and genomic analysis, this consortium aims to explore putative predictive biomarkers with the potential to inform personalized treatment strategies. Findings from the REFINE database may further contribute to our understanding of disease courses of immunotherapy-based approaches for various molecular subtypes of RCC, associations of race and ethnicity with RCC treatment and outcomes with representation of patient populations underrepresented in clinical trials, and optimizing treatment sequencing.

Genomics

Biomarkers, Tumor - genetics

Carcinoma, Renal Cell - drug therapy

Carcinoma, Renal Cell - genetics

Carcinoma, Renal Cell - pathology

Carcinoma, Renal Cell - therapy

Databases, Factual

Humans

Immunotherapy - methods

Kidney Neoplasms - drug therapy

Kidney Neoplasms - genetics

Kidney Neoplasms - pathology

Kidney Neoplasms - therapy

Details

Title: Subtitle: REFINE: a database of linked clinical data and genomic biomarkers in renal cell carcinoma patients receiving immunotherapy-based treatment regimens
Creators: Jeffrey Zhong - University Hospitals of Cleveland
Albert Jang - University Hospitals of Cleveland
Bashar Abuqayas - University of Iowa Holden Comprehensive Cancer Center
Arnab Basu - University of Alabama at Birmingham
David J Benjamin - Hoag Memorial Hospital Presbyterian
Vineel Bhatlapenumarthi - Medical College of Wisconsin
Mehmet Asim Bilen - Emory University
Dhvani Buch - Wake Forest Baptist Comprehensive Cancer Center
Mark Chang - Wake Forest Baptist Comprehensive Cancer Center
Erica Chin - Moores Cancer Center
Sourat Darabi - Hoag Memorial Hospital Presbyterian
Nagendra Dhanikonda - Fox Chase Cancer Center
Pooja Ghatalia - Fox Chase Cancer Center
Claud M Grigg - Wake Forest Baptist Comprehensive Cancer Center
Abby L Grier - University Hospitals of Cleveland
Tanya Jindal - University Hospitals of Cleveland
Joannah Jung - Moores Cancer Center
Deepak Kilari - Medical College of Wisconsin
Hamsa L S Kumar - University Hospitals of Cleveland
Suzanna Lee - University of California San Diego
Brittany Neelands - Wake Forest Baptist Comprehensive Cancer Center
Chinmayi Pandya - University of California San Diego
Jeff Pawalek - University of California San Diego
Jaimee Staggers - University of Alabama
Ahmet Yildirim - Emory University
Yousef Zakharia - University of Iowa Holden Comprehensive Cancer Center
Kevin K Zarrabi - Sidney Kimmel Cancer Center
Michael Zimmerman - Sidney Kimmel Cancer Center
George Sledge - Caris Life Sciences (United States)
David Spetzler - Caris Life Sciences (United States)
Andrew Elliott - Caris Life Sciences (United States)
Rana R McKay - University of California San Diego
Pedro C Barata - University Hospitals of Cleveland
Resource Type: Journal article
Publication Details: The oncologist (Dayton, Ohio), Vol.30(6), oyaf135
DOI: 10.1093/oncolo/oyaf135
PMID: 40536267
PMCID: PMC12204391
NLM abbreviation: Oncologist
ISSN: 1549-490X
eISSN: 1549-490X
Publisher: OXFORD UNIV PRESS; OXFORD
Grant note: Exelixis and Kure It Research
Language: English
Date published: 06/04/2025
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; General Internal Medicine; Internal Medicine
Record Identifier: 9984832189002771

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