Journal article
REM sleep twitches rouse nascent cerebellar circuits: Implications for sensorimotor development
Developmental neurobiology (Hoboken, N.J.), Vol.75(10), pp.1140-1153
10/2015
DOI: 10.1002/dneu.22177
PMCID: PMC4177987
PMID: 24677804
Abstract
The cerebellum is critical for sensorimotor integration and undergoes extensive postnatal development. During the first postnatal week in rats, climbing fibers polyinnervate Purkinje cells and, before granule cell migration, mossy fibers make transient, direct connections with Purkinje cells. Activity-dependent processes are assumed to play a critical role in the development and refinement of these and other aspects of cerebellar circuitry. However, the sources and patterning of activity have not been described. We hypothesize that sensory feedback (i.e., reafference) from myoclonic twitches in sleeping newborn rats is a prominent driver of activity for the developing cerebellum. Here, in 6-day-old rats, we show that Purkinje cells exhibit substantial state-dependent changes in complex and simple spike activity-primarily during active sleep. In addition, this activity increases significantly during bouts of twitching. Moreover, the surprising observation of twitch-dependent increases in simple spike activity at this age suggests a functional engagement of mossy fibers before the parallel fiber system has developed. Based on these and other results, we propose that twitching comprises a unique class of self-produced movement that drives critical aspects of activity-dependent development in the cerebellum and other sensorimotor systems.
Details
- Title: Subtitle
- REM sleep twitches rouse nascent cerebellar circuits: Implications for sensorimotor development
- Creators
- Greta Sokoloff - Delta Center, The University of Iowa, Iowa City, IowaBrandt D Uitermarkt - Department of Psychology, University of Iowa, Iowa City, IowaMark S Blumberg - Department of Biology, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Developmental neurobiology (Hoboken, N.J.), Vol.75(10), pp.1140-1153
- DOI
- 10.1002/dneu.22177
- PMID
- 24677804
- PMCID
- PMC4177987
- NLM abbreviation
- Dev Neurobiol
- ISSN
- 1932-8451
- eISSN
- 1932-846X
- Publisher
- Wiley; United States
- Grant note
- R01 HD063071 / NICHD NIH HHS HD63071 / NICHD NIH HHS
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070467702771
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