Journal article
RESTING AND EXERCISE ELECTROCARDIOGRAPHIC ABNORMALITIES ASSOCIATED WITH SEX HORMONE USE IN WOMEN
American journal of epidemiology, Vol.123(1), pp.81-88
01/1986
DOI: 10.1093/oxfordjournals.aje.a114226
Abstract
Prevalence rates for resting and exercise electrocardiographic abnormalities were determined according to the use or nonuse of oral contraceptives and exogenous estrogens in 1,919 women participants from 10 defined North American study populations of the Lipid Research Clinics Program. Among women 30–49 years of age, no significant differences in the prevalence of resting electrocardiographic abnormalities between oral contraceptive users and nonusers were seen after adjustment for age, blood pressure, cigarette smoking, alcohol, and obesity. Abnormal graded exercise electrocardiograms, however, were more prevalent among the oral contraceptive users (odds ratio = 2.7, p<0.05). Among women 50 years and older, a significant deficit of abnormal Q waves on resting electrocardiogram and nonsignificant excess of abnormal S-T segment responses to exercise were noted in estrogen users compared with nonusers. Possible sources of bias and the pathophysiologic implications of these findings are discussed.
Details
- Title: Subtitle
- RESTING AND EXERCISE ELECTROCARDIOGRAPHIC ABNORMALITIES ASSOCIATED WITH SEX HORMONE USE IN WOMEN
- Creators
- ELIZABETH BARRETT-CONNOR - University of California San DiegoTIMOTHY Wilcosky - University of North Carolina at Chapel HillROBERT B. Wallace - University of IowaGERARDO Heiss - Departments of Biostatistics and Epidemiology, School of Public Health, University of North CarolinaChapel Hill, NC
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.123(1), pp.81-88
- DOI
- 10.1093/oxfordjournals.aje.a114226
- ISSN
- 0002-9262
- eISSN
- 1476-6256
- Publisher
- Oxford University Press
- Language
- English
- Date published
- 01/1986
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364411002771
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