Journal article
RIT2 Polymorphisms: Is There a Differential Association?
Molecular neurobiology, Vol.54(3), pp.2234-2240
04/2017
DOI: 10.1007/s12035-016-9815-4
PMID: 26941103
Abstract
Neurological disorders include a wide variety of mostly multifactorial diseases related to the development, survival, and function of the neuron cells. Single-nucleotide polymorphisms (SNPs) have been extensively studied in neurological disorders, and in a number of instances have been reproducibly linked to disease as risk factors. The RIT2 gene has been recently shown to be associated with a number of neurological disorders, such as Parkinson's disease (PD) and autism. In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders.
Details
- Title: Subtitle
- RIT2 Polymorphisms: Is There a Differential Association?
- Creators
- Babak Emamalizadeh - Shahid Beheshti University of Medical SciencesJavad Jamshidi - Fasa University of Medical SciencesAbolfazl Movafagh - Shahid Beheshti University of Medical SciencesMina Ohadi - University of Social Welfare and Rehabilitation SciencesMahmoud Shekari Khaniani - Tabriz University of Medical SciencesSomayyeh Kazeminasab - University of Social Welfare and Rehabilitation SciencesAkbar Biglarian - University of Social Welfare and Rehabilitation SciencesShaghayegh Taghavi - Shahid Beheshti University of Medical SciencesMarzieh Motallebi - Shahid Beheshti University of Medical SciencesAtena Fazeli - Shahid Beheshti University of Medical SciencesAzadeh Ahmadifard - Shahid Beheshti University of Medical SciencesGholam-Ali Shahidi - Iran University of Medical SciencesPeyman Petramfar - Shiraz University of Medical SciencesNeda Shahmohammadibeni - Babol University of Medical SciencesTahereh Dadkhah - Babol University of Medical SciencesEhteram Khademi - Babol University of Medical SciencesAbbas Tafakhori - Imam Khomeini HospitalAli Khaligh - Sabzevar University of Medical SciencesTannaz Safaralizadeh - Shahid Beheshti University of Medical SciencesAli Kowsari - Golestan UniversityArash Mirabzadeh - University of Social Welfare and Rehabilitation SciencesAmir Ehtesham Shafiei Zarneh - Shahid Beheshti University of Medical SciencesMehdi Khorrami - Isfahan University of Medical SciencesParasto Shokraeian - Islamic Azad University Medical Branch of TehranMohammad Javad Soltani Banavandi - Islamic Azad University KermanBehnam Safarpour Lima - Imam Hossein HospitalMonavvar Andarva - Shahid Beheshti University of Medical SciencesElham Alehabib - Shahid Beheshti University of Medical SciencesMinoo Atakhorrami - Shahid Beheshti University of Medical SciencesHossein Darvish - Shahid Beheshti University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- Molecular neurobiology, Vol.54(3), pp.2234-2240
- DOI
- 10.1007/s12035-016-9815-4
- PMID
- 26941103
- NLM abbreviation
- Mol Neurobiol
- ISSN
- 0893-7648
- eISSN
- 1559-1182
- Language
- English
- Date published
- 04/2017
- Academic Unit
- Neurology
- Record Identifier
- 9985014709202771
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