Journal article
RNA Interference: A Tool for Querying Nervous System Function and an Emerging Therapy
Neuron (Cambridge, Mass.), Vol.53(6), pp.781-788
2007
DOI: 10.1016/j.neuron.2007.02.020
PMID: 17359914
Abstract
RNA interference (RNAi), a mediator of gene silencing, has swiftly become one of the most exciting and applicable biological discoveries. There has been rapid progress in identifying RNAi pathway components and elucidating the mechanisms of microRNA (miRNA) biogenesis and gene suppression. As a result, RNAi technologies have been successfully employed in a variety of systems as biological tools, and studies are underway to test the therapeutic utility of RNAi. In the span of several years, significant advances in the delivery of inhibitory RNAs in the nervous system have been made. We have glimpses into how endogenous miRNAs interface with neuronal development and function; in addition, RNAi has shown therapeutic efficacy in several mouse models of human neurological conditions. In this review, we summarize the current state-of-the-art of RNAi and its utility to neuroscientists.
Details
- Title: Subtitle
- RNA Interference: A Tool for Querying Nervous System Function and an Emerging Therapy
- Creators
- Beverly L Davidson - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USARyan L Boudreau - Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.53(6), pp.781-788
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.neuron.2007.02.020
- PMID
- 17359914
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Language
- English
- Date published
- 2007
- Academic Unit
- Iowa Neuroscience Institute; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984065390402771
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