RNA Localization in the Vertebrate Oocyte: Establishment of Oocyte Polarity and Localized mRNA Assemblages

Denise Oh; Douglas W Houston

doi:10.1007/978-3-319-60855-6_9

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Journal article

RNA Localization in the Vertebrate Oocyte: Establishment of Oocyte Polarity and Localized mRNA Assemblages

Denise Oh and Douglas W Houston

Results and problems in cell differentiation, Vol.63, pp.189-208

2017

DOI: 10.1007/978-3-319-60855-6_9

PMCID: PMC6538070

PMID: 28779319

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https://www.ncbi.nlm.nih.gov/pmc/articles/6538070View

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Abstract

RNA localization is a fundamental mechanism for controlling cell structure and function. Early development in fish and amphibians requires the localization of specific mRNAs to establish the initial differences in cell fates prior to the onset of zygotic genome activation. RNA localization in these oocytes (e.g., Xenopus and zebrafish) requires that animal-vegetal polarity be established early in oogenesis, mediated by formation of the Balbiani body/mitochondrial cloud. This structure serves as a platform for assembly and transport of germline determinants to the future vegetal pole and also sets up the machinery for the localization of non-germline transcripts later in oogenesis. Understanding these polarization and localization mechanisms is critical for understanding the basis for early embryonic development in these organisms and also for understanding the role of RNA compartmentalization in animal gametogenesis. Here we outline recent advances in elucidating the molecular basis for the establishment of oocyte polarity at the level of Balbiani body assembly as well as the formation of RNP assemblies for early and late pathway mRNA localization in the oocyte.

Cell Polarity

Oocytes - cytology

Animals

RNA Transport

Oocytes - metabolism

RNA, Messenger - analysis

Female

Oogenesis - genetics

RNA, Messenger - metabolism

Details

Title: Subtitle: RNA Localization in the Vertebrate Oocyte: Establishment of Oocyte Polarity and Localized mRNA Assemblages
Creators: Denise Oh - Department of Biology, The University of Iowa, 257 BB, Iowa City, IA, 52242, USA
Douglas W Houston - Department of Biology, The University of Iowa, 257 BB, Iowa City, IA, 52242, USA. douglas-houston@uiowa.edu
Resource Type: Journal article
Publication Details: Results and problems in cell differentiation, Vol.63, pp.189-208
DOI: 10.1007/978-3-319-60855-6_9
PMID: 28779319
PMCID: PMC6538070
NLM abbreviation: Results Probl Cell Differ
ISSN: 0080-1844
eISSN: 1861-0412
Publisher: Germany
Grant note: R01 GM083999 / NIGMS NIH HHS
Language: English
Date published: 2017
Academic Unit: Biology
Record Identifier: 9983992035202771

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