Journal article
RNA polymerase II elongation control
Annual review of biochemistry, Vol.81(1), pp.119-143
2012
DOI: 10.1146/annurev-biochem-052610-095910
PMCID: PMC4273853
PMID: 22404626
Abstract
Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized extensively to generate the pattern of mRNAs needed to specify cell types and to respond to environmental changes. After Pol II initiates, negative elongation factors cause it to pause in a promoter proximal position. These polymerases are poised to respond to the positive transcription elongation factor P-TEFb, and then enter productive elongation only under the appropriate set of signals to generate full-length properly processed mRNAs. Recent global analyses of Pol II and elongation factors, mechanisms that regulate P-TEFb involving the 7SK small nuclear ribonucleoprotein (snRNP), factors that control both the negative and positive elongation properties of Pol II, and the mRNA processing events that are coupled with elongation are discussed.
Details
- Title: Subtitle
- RNA polymerase II elongation control
- Creators
- Qiang Zhou - Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA. qzhou@berkeley.eduTiandao LiDavid H Price
- Resource Type
- Journal article
- Publication Details
- Annual review of biochemistry, Vol.81(1), pp.119-143
- DOI
- 10.1146/annurev-biochem-052610-095910
- PMID
- 22404626
- PMCID
- PMC4273853
- NLM abbreviation
- Annu Rev Biochem
- ISSN
- 0066-4154
- eISSN
- 1545-4509
- Publisher
- United States
- Grant note
- R21 AI074392 / NIAID NIH HHS AI41757 / NIAID NIH HHS AI095057 / NIAID NIH HHS GM35500 / NIGMS NIH HHS R01 AI041757 / NIAID NIH HHS R33 AI074392 / NIAID NIH HHS AI074392 / NIAID NIH HHS R01 GM035500 / NIGMS NIH HHS
- Language
- English
- Date published
- 2012
- Academic Unit
- Surgery; Biochemistry and Molecular Biology
- Record Identifier
- 9984025282802771
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