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ROLE OF GLUCAGON IN HUMAN DIABETIC KETOACIDOSIS: STUDIES USING SOMATOSTATIN
Journal article   Peer reviewed

ROLE OF GLUCAGON IN HUMAN DIABETIC KETOACIDOSIS: STUDIES USING SOMATOSTATIN

JOHN E GERICH, VICTOR S SCHNEIDER, MARA LORENZI, EVA TSALIKIAN, JOHN H KARAM, DENNIS M BIER and PETER H FORSHAM
Clinical endocrinology (Oxford), Vol.5(s1), pp.s299-s305
02/1976
DOI: 10.1111/j.1365-2265.1976.tb03838.x
PMID: 829924

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Abstract

The present studies demonstrate that endogenous glucagon is hyperglycaemic, lipolytic and ketogenic in man, and that insulin deficiency is necessary, but is in itself not sufficient, to cause fulminant diabetic ketoacidosis. Furthermore, continuous elevation of endogenous glucagon secretion appears to be necessary for the maintenance and continued development of the characteristic metabolic consequences of insulin lack.

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