ROR1, an embryonic protein with an emerging role in cancer biology

Nicholas Borcherding; David Kusner; Guang-Hui Liu; Weizhou Zhang

doi:10.1007/s13238-014-0059-7

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ROR1, an embryonic protein with an emerging role in cancer biology

Journal article

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ROR1, an embryonic protein with an emerging role in cancer biology

Nicholas Borcherding, David Kusner, Guang-Hui Liu and Weizhou Zhang

Protein & cell, Vol.5(7), pp.496-502

07/2014

DOI: 10.1007/s13238-014-0059-7

PMCID: PMC4085287

PMID: 24752542

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Abstract

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Within the intracellular portion, ROR1 possesses a tyrosine kinase domain, two serine/threonine-rich domains and a proline-rich domain. RORs have been studied in the context of embryonic patterning and neurogenesis through a variety of homologs. These physiologic functions are dichotomous based on the requirement of the kinase domain. A growing literature has established ROR1 as a marker for cancer, such as in CLL and other blood malignancies. In addition, ROR1 is critically involved in progression of a number of blood and solid malignancies. ROR1 has been shown to inhibit apoptosis, potentiate EGFR signaling, and induce epithelial-mesenchymal transition (EMT). Importantly, ROR1 is only detectable in embryonic tissue and generally absent in adult tissue, making the protein an ideal drug target for cancer therapy.

Embryogenesis

Immunotherapy

ROR1

cancer

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Details

Title: Subtitle: ROR1, an embryonic protein with an emerging role in cancer biology
Creators: Nicholas Borcherding - Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242 USA
David Kusner - University of Iowa, Internal Medicine
Guang-Hui Liu - National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China
Weizhou Zhang - Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242 USA
Resource Type: Journal article
Publication Details: Protein & cell, Vol.5(7), pp.496-502
DOI: 10.1007/s13238-014-0059-7
PMID: 24752542
PMCID: PMC4085287
NLM abbreviation: Protein Cell
ISSN: 1674-800X
eISSN: 1674-8018
Publisher: Higher Education Press
Language: English
Date published: 07/2014
Academic Unit: Dermatology; Radiation Oncology; Internal Medicine
Record Identifier: 9984083269002771

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