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Rabbit Model for Superantigen-Mediated Lethal Pulmonary Disease
Journal article

Rabbit Model for Superantigen-Mediated Lethal Pulmonary Disease

Kristi L Strandberg, Jessica H Rotschafer and Patrick M Schlievert
Methods in molecular biology (Clifton, N.J.), Vol.1396, pp.81-93
2016
DOI: 10.1007/978-1-4939-3344-0_7
PMID: 26676039

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Abstract

Staphylococcus aureus is a highly significant cause of serious human infections in the USA. Many of these illnesses are mediated by interactions between the host immune system and staphylococcal superantigens (SAgs). Several of these severe staphylococcal infections are initiated in the lungs, making this an important site to study. Here, we describe the rabbit model for investigating the role of staphylococcal SAgs in pulmonary-associated lethal infection and intoxication.
Lung Diseases - immunology Rabbits Antibodies, Bacterial - administration & dosage Immunization Animals Lung Diseases - microbiology Lung Diseases - prevention & control Lung Diseases - mortality Antibodies, Bacterial - immunology Staphylococcus aureus - immunology Superantigens - immunology Disease Models, Animal

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