Journal article
Race, Income, and Disease Outcomes in Juvenile Dermatomyositis
The Journal of pediatrics, Vol.184, pp.38-44.e1
05/2017
DOI: 10.1016/j.jpeds.2017.01.046
PMCID: PMC5410644
PMID: 28410093
Abstract
To determine the relationships among race, income, and disease outcomes in children with juvenile dermatomyositis (JDM).
Data from 438 subjects with JDM enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry were analyzed. Demographic data included age, sex, race, annual family income, and insurance status. Clinical outcomes included muscle strength, presence of rash, calcinosis, weakness, physical function, and quality of life measures. Disease outcomes were compared based on race and income.
Minority subjects were significantly more likely to have low annual family income and significantly worse scores on measures of physical function, disease activity, and quality of life measures. Subjects with lower annual family income had worse scores on measures of physical function, disease activity, and quality of life scores, as well as weakness. Black subjects were more likely to have calcinosis. Despite these differences in outcome measures, there were no significant differences among the racial groups in time to diagnosis or duration of disease. Using calcinosis as a marker of disease morbidity, black race, annual family income <$50 000 per year, negative antinuclear antibody, and delay in diagnosis >12 months were associated with calcinosis.
Minority race and lower family income are associated with worse morbidity and outcomes in subjects with JDM. Calcinosis was more common in black subjects. Further studies are needed to examine these associations in more detail, to support efforts to address health disparities in subjects with JDM and improve disease outcomes.
Details
- Title: Subtitle
- Race, Income, and Disease Outcomes in Juvenile Dermatomyositis
- Creators
- Kathryn Phillippi - Division of Pediatric Infectious Diseases and Rheumatology, Rainbow Babies and Children's Hospital/Case Medical Center, Cleveland, OHPolly J Ferguson - University of Iowa Carver College of Medicine, Iowa City, IAMark Hoeltzel - Division of Pediatric Rheumatology, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MIAngela Byun Robinson - Division of Pediatric Infectious Diseases and Rheumatology, Rainbow Babies and Children's Hospital/Case Medical Center, Cleveland, OHSusan Kim - Division of Rheumatology, University of California at San Francisco, Benioff Children's Hospital, San Francisco, CALeslie S Abramson - University of Vermont College of Medicine, Burlington, VTEleanor S Anderson - Permanente Medical Group, Union City, CAMara L Becker - Children's Mercy Hospitals and Clinics, Kansas City, MOHeather Benham - Texas Scottish Rite Hospital, Dallas, TXTimothy Beukelman - University of Alabama-Birmingham, ALPeter R Blier - Baystate Children's Hospital, Springfield, MAHermine I Brunner - Cincinnati Children's Hopsital Medical Center, Cincinnati, OHJoni Dean - American Family Children's Hospital, Madison, WIFatma Dedeoglu - Boston Children's Hospital, Boston, MABrian M Feldman - The Hospital for Sick Children, Toronto, ONDonald P Goldsmith - St. Christopher's Hospital for Children, Philadelphia, PABeth S Gottlieb - Cohen Children's Medical Center, New Hyde Park, NYThomas B Graham - Vanderbilt Children's Hospital, Nashville, TNThomas A Griffin - Levine Children's Hospital, Carolinas Medical Center, Charlotte, NCHilary M Haftel - University of Michigan Medical Center, Ann Arber, MIGloria C Higgins - Nationwide Children's Hospital, Columbus, OHJ.R Hollister - University of Colorado, Colorado Springs, COJoyce J Hsu - Stanford University, Palo Alto, CAAnna Huttenlocher - University of Wisconsin School of Medicine, Madison, WINorman T Ilowite - Children's Hospital of Montefiore, Bronx, NYLisa F Imundo - Columbia University Medical Center, New York, NYRita S Jerath - Children's Hospital of Georgia, Augusta, GALawrence K Jung - Children's National Medical Center, Washington, DCPhilip J Kahn - New York University, New York, NYDaniel J Kingsbury - Randall Children's Hospital at Legacy Emanuel, Portland, ORKristin E Klein - University of Louisville, Louisville, KYMarisa S Klein-Gitelman - Lurie Children's Hospital of Chicago, Northwestern University, Chicago, ILSivia K Lapidus - Goryeb Children's Hospital, Morristown, NJThomas J.A Lehman - Hospital for Special Surgery, New York, NYCarol B Lindsley - University of Kansas City Medical Center, Kansas City, KSMichael A Malloy - Warren Clinic, Tulsa, OKDeborah K McCurdy - Mattel Children's UCLA, Los Angeles, CAEyal Muscal - Baylor College of Medicine, Houston, TXJudyann C Olson - Medical College of Wisconsin, Milwaukee, WIKathleen M O'Neil - Riley Hospital for Children, Indianapolis, INKaren Onel - University of Chicago, Chicago, ILSampath Prahalad - Emory Children's Center, Atlanta, GAMarilynn G Punaro - Texas Scottish Rite Hospital, Dallas, TXC. Egla Rabinovich - Emory Children's Center, Atlanta, GAAnn M Reed - Duke University, Durham, NCSarah Ringold - Seattle Children's Hospital, Bellevue, WAMary Ellen Riordan - Hackensack University Medical Center, Hackensack, NJDeborah Rothman - Albany Medical Center, Albany, NYNatasha M Ruth - The Medical University of South Carolinam, Charleston, SCKenneth N Schikler - University of Louisville School of Medicine, Louisville, KYNora G Singer - MetroHealth Center, Cleveland, OHSteven Spalding - Phoenix Children's Hospital, Phoenix, AZReema H Syed - St. Louis University, St. Louis, MOKathryn S Torok - University of Pittsburgh Medical Center, Pittsburgh, PAJenna Tress - The Children's Hospital of Philadelphia, Philadelphia, PARichard K Vehe - University of Minnesota, Minneapolis, MNEmily Von Scheven - University of California-San Francisco, San Francisco, CALydia M Walters - University of Miss Medical Center, Jackson, MSJennifer E Weiss - Hackensack University Medical Center, Hackensack, NJPamela Weiss - The Children's Hospital of Philadelphia, Philadelphia, PAAndrew J White - St. Louis Children's Hospital, St. Louis, MOJennifer M Woo - Milwaukee, WIAli Yalcindag - Hasbro Children's Hospital, Providence, RILawrence S Zemel - Connecticut Children's Medical Center, Harford, CT
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.184, pp.38-44.e1
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpeds.2017.01.046
- PMID
- 28410093
- PMCID
- PMC5410644
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Grant note
- T32 AR007505; RC2AR058934 / NIAMS (http://dx.doi.org/10.13039/100000069) Duke Clinical Research Institute (http://dx.doi.org/10.13039/100006513)
- Language
- English
- Date published
- 05/2017
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984070759602771
Metrics
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