Race and ethnicity representation in clinical trials: findings from a literature review of Phase I oncology trials

D Ross Camidge; Haeseong Park; Karen E Smoyer; Ira Jacobs; Lauren J Lee; Zemfira Askerova; Justin McGinnis; Yousef Zakharia

doi:10.2217/fon-2020-1262

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Race and ethnicity representation in clinical trials: findings from a literature review of Phase I oncology trials

Journal article

Open access

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Race and ethnicity representation in clinical trials: findings from a literature review of Phase I oncology trials

D Ross Camidge, Haeseong Park, Karen E Smoyer, Ira Jacobs, Lauren J Lee, Zemfira Askerova, Justin McGinnis and Yousef Zakharia

Future oncology (London, England), Vol.17(24), pp.3271-3280

08/01/2021

DOI: 10.2217/fon-2020-1262

PMID: 34047192

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Abstract

To provide an assessment of published literature on the demographic representation in Phase I trials of biopharmaceutical oncology agents. We conducted a rapid evidence assessment to identify demographic representation reported in Phase I clinical trials for biopharmaceutical oncology agents published in 2019. Globally, the population was predominantly White/Caucasian (62.2%). In the USA, the distribution was heavily skewed toward White/Caucasian (84.2%), with minimal representation of Blacks/African-Americans (7.3%), Asians (3.4%), Hispanics/Latinos (2.8%) or other race/ethnicity groups. Our data highlight that Phase I oncology trials do not reflect the population at large, which may perpetuate health disparities. Further research is needed to understand and address barriers to participation, particularly among under-represented groups.

Antineoplastic Agents - therapeutic use

Clinical Trials, Phase I as Topic - statistics & numerical data

Ethnicity - statistics & numerical data

Healthcare Disparities - statistics & numerical data

Humans

Medical Oncology - statistics & numerical data

Neoplasms - drug therapy

Racial Groups - statistics & numerical data

Details

Title: Subtitle: Race and ethnicity representation in clinical trials: findings from a literature review of Phase I oncology trials
Creators: D Ross Camidge - University of Colorado Hospital
Haeseong Park - Washington University in St. Louis
Karen E Smoyer - Envision Pharma Group, Philadelphia, PA 19109, USA
Ira Jacobs - Pfizer (United States)
Lauren J Lee - Pfizer (United States)
Zemfira Askerova - Pfizer (United States)
Justin McGinnis - Pfizer (United States)
Yousef Zakharia - University of Iowa
Resource Type: Journal article
Publication Details: Future oncology (London, England), Vol.17(24), pp.3271-3280
DOI: 10.2217/fon-2020-1262
PMID: 34047192
NLM abbreviation: Future Oncol
ISSN: 1479-6694
eISSN: 1744-8301
Language: English
Date published: 08/01/2021
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984548378402771

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