Journal article
Race, ethnicity and risk of second primary contralateral breast cancer in the United States
International journal of cancer, Vol.148(11), pp.2748-2758
06/2021
DOI: 10.1002/ijc.33501
PMCID: PMC9059169
PMID: 33544892
Abstract
Breast cancer survivors have a high risk of a second primary contralateral breast cancer (CBC), but there are few studies of CBC risk in racial/ethnic minority populations. We examined whether the incidence and risk factors for CBC differed by race/ethnicity in the United States. Women with a first invasive Stage I-IIB breast cancer diagnosis at ages 20-74 years between 2000 and 2015 in the Surveillance, Epidemiology, and End Results Program (SEER) 18 registries were followed through 2016 for a diagnosis of invasive CBC ≥1 year after the first breast cancer diagnosis. We used cause-specific Cox proportional hazards models to test the association between race/ethnicity and CBC, adjusting for age, hormone receptor status, radiation therapy, chemotherapy and stage at first diagnosis, and evaluated the impact of contralateral prophylactic mastectomy, socioeconomic status, and insurance status on the association. After a median follow-up of 5.9 years, 9247 women (2.0%) were diagnosed with CBC. Relative to non-Hispanic (NH) White women, CBC risk was increased in NH Black women (hazard ratio = 1.44, 95% CI 1.35-1.54) and Hispanic women (1.11, 95% CI 1.02-1.20), with the largest differences among women diagnosed at younger ages. Adjustment for contralateral prophylactic mastectomy, socioeconomic status and health insurance did not explain the associations. Therefore, non-Hispanic Black and Hispanic women have an increased risk of CBC that is not explained by clinical or socioeconomic factors collected in SEER. Large studies of diverse breast cancer survivors with detailed data on treatment delivery and adherence are needed to inform interventions to reduce this disparity.
Details
- Title: Subtitle
- Race, ethnicity and risk of second primary contralateral breast cancer in the United States
- Creators
- Gordon P Watt - Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York New York USAEsther M John - Department of Epidemiology and Population Health Stanford University School of Medicine Stanford California USAElisa V Bandera - Cancer Epidemiology and Health Outcomes Rutgers Cancer Institute of New Jersey New Brunswick New Jersey USAKathleen E Malone - Epidemiology Program, Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington USACharles F Lynch - Department of Epidemiology University of Iowa Iowa City Iowa USAJulie R Palmer - Department of Medicine Boston University School of Medicine Boston Massachusetts USAJulia A Knight - Prosserman Centre for Population Health Research Lunenfeld‐Tanenbaum Research Institute, Sinai Health System Toronto Ontario CanadaMelissa A Troester - Department of Epidemiology University of North Carolina Gillings School of Global Public Health Chapel Hill North Carolina USAJonine L Bernstein - Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York New York USA
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.148(11), pp.2748-2758
- DOI
- 10.1002/ijc.33501
- PMID
- 33544892
- PMCID
- PMC9059169
- NLM abbreviation
- Int J Cancer
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Grant note
- DOI: 10.13039/100000054, name: NCI, award: P30CA008748, R01CA097397, R01CA114236, R01CA129639, U01CA083178
- Language
- English
- Date published
- 06/2021
- Academic Unit
- Epidemiology
- Record Identifier
- 9984214718002771
Metrics
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