Journal article
Racial Differences in CT Phenotypes in COPD
Chronic obstructive pulmonary disease, Vol.10(1), pp.20-27
01/16/2013
DOI: 10.3109/15412555.2012.727921
PMCID: PMC4321889
PMID: 23413893
Abstract
Background: Whether African Americans (AA) are more susceptible to COPD than non-Hispanic Whites (NHW) and whether racial differences in disease phenotype exist is controversial. The objective is to determine racial differences in the extent of emphysema and airway remodeling in COPD. Methods: First, 2,500 subjects enrolled in the COPDGene study were used to evaluate racial differences in quantitative CT (QCT) parameters of% emphysema, air trapping and airway wall thickness. Independent variables studied included race, age, gender, education, BMI, pack-years, smoking status, age at smoking initiation, asthma, previous work in dusty job, CT scanner and center of recruitment. Results: Of the 1,063 subjects with GOLD Stage II-IV COPD, 200 self-reported as AA. AAs had a lower mean% emphysema (13.1% vs. 16.1%, p = 0.005) than NHW and proportionately less emphysema in the lower lung zones. After adjustment for covariates, there was no statistical difference by race in air trapping or airway wall thickness. Measured QCT parameters were more predictive of poor functional status in NHWs compared to AAs. Conclusions: AAs have less emphysema than NHWs but the same degree of airway disease. Additional factors not easily assessed by current QCT techniques may account for the poor functional status in AAs.
Details
- Title: Subtitle
- Racial Differences in CT Phenotypes in COPD
- Creators
- Nadia N Hansel - 1Johns Hopkins UniversityGeorge R Washko - 2Channing Laboratory, Brigham and Women's Hospital and Harvard Medical SchoolMarilyn G Foreman - 3Morehouse School of MedicineMeiLan K Han - 4University of Michigan Health SystemEric A Hoffman - 5University of IowaDawn L DeMeo - 2Channing Laboratory, Brigham and Women's Hospital and Harvard Medical SchoolR. Graham Barr - 6Columbia UniversityEdwin J.R Van Beek - 7University of EdinburghElla A Kazerooni - 4University of Michigan Health SystemRobert A Wise - 1Johns Hopkins UniversityRobert H Brown - 1Johns Hopkins UniversityJennifer Black-Shinn - 8University of ColoradoJohn E Hokanson - 8University of ColoradoNicola A Hanania - 9Baylor College of MedicineBarry Make - 10National Jewish HealthEdwin K Silverman - 2Channing Laboratory, Brigham and Women's Hospital and Harvard Medical SchoolJames D Crapo - 10National Jewish HealthMark T Dransfield - 11University of Alabama - BirminghamCOPDGene Investigators
- Resource Type
- Journal article
- Publication Details
- Chronic obstructive pulmonary disease, Vol.10(1), pp.20-27
- Publisher
- Taylor & Francis
- DOI
- 10.3109/15412555.2012.727921
- PMID
- 23413893
- PMCID
- PMC4321889
- ISSN
- 1541-2555
- eISSN
- 1541-2563
- Language
- English
- Date published
- 01/16/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051526202771
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