Racial and Ethnic Differences in Advanced-Stage Prostate Cancer: the Prostate Cancer Outcomes Study

Richard M Hoffman; Frank D Gilliland; J. William Eley; Linda C Harlan; Robert A Stephenson; Janet L Stanford; Peter C Albertson; Ann S Hamilton; W. Curtis Hunt; Arnold L Potosky

doi:10.1093/jnci/93.5.388

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Racial and Ethnic Differences in Advanced-Stage Prostate Cancer: the Prostate Cancer Outcomes Study

Journal article

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Racial and Ethnic Differences in Advanced-Stage Prostate Cancer: the Prostate Cancer Outcomes Study

Richard M Hoffman, Frank D Gilliland, J. William Eley, Linda C Harlan, Robert A Stephenson, Janet L Stanford, Peter C Albertson, Ann S Hamilton, W. Curtis Hunt and Arnold L Potosky

JNCI : Journal of the National Cancer Institute, Vol.93(5), pp.388-395

03/07/2001

DOI: 10.1093/jnci/93.5.388

PMID: 11238701

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Abstract

Background: African-Americans have twice the risk of non-Hispanic whites for presenting with advanced-stage prostate cancer. To investigate the reasons for this difference, we evaluated the association between race/ethnicity and advanced-stage prostate cancer, adjusting for demographic, socioeconomic, clinical, and pathologic factors. Methods: A population-based cohort of 3173 men diagnosed with prostate cancer between October 1, 1994, and October 31, 1995, was analyzed. Medical record abstracts and self-administered survey questionnaires were used to obain information regarding race/ethnicity, age, marital status, insurance status, educational level, household income, employment status, comorbidity, urinary function, prostate-specific antigen level, tumor grade, and clinical stage. The odds ratio (OR) for advanced-stage prostate cancer was estimated with weighted logistic regression analysis. All P values were two-sided. Results: Clinically advanced-stage prostate cancers were detected more frequently in African-Americans (12.3%) and Hispanics (10.5%) than in non-Hispanic whites (6.3%). Socioeconomic, clinical, and pathologic factors each accounted for about 15% of the increased relative risk. After adjusting for all covariates, the risk remained statistically significantly increased for African-Americans (OR = 2.26; 95% confidence interval [CI] = 1.43 to 3.58) but not for Hispanics (OR = 1.23; 95% CI = 0.73 to 2.08). Conclusion: Traditional socioeconomic, clinical, and pathologic factors accounted for the increased relative risk for presenting with advanced-stage prostate cancer in Hispanic but not in African-American men.

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Title: Subtitle: Racial and Ethnic Differences in Advanced-Stage Prostate Cancer: the Prostate Cancer Outcomes Study
Creators: Richard M Hoffman - Affiliations of authors: R. M. Hoffman, Medicine Service, Department of Veterans Affairs Medical Center, Albuquerque, NM, and New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque; W. C. Hunt, New Mexico Tumor Registry, University of New Mexico Health Sciences Center; F. D. Gilliland, A. S. Hamilton, Department of Preventive Medicine, University of Southern California, Los Angeles; J. W. Eley, Georgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA; L. C. Harlan, A. L. Potosky, Division of Cancer Control and Prevention, National Cancer Institute, Bethesda, MD; R. A. Stephenson, Utah Cancer Registry and Division of Urology, University of Utah School of Medicine, Salt Lake City; J. L. Stanford, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington; P. C. Albertson, Division of Urology, University of Connecticut Health Sciences Center, Farmington
Frank D Gilliland - Affiliations of authors: R. M. Hoffman, Medicine Service, Department of Veterans Affairs Medical Center, Albuquerque, NM, and New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque; W. C. Hunt, New Mexico Tumor Registry, University of New Mexico Health Sciences Center; F. D. Gilliland, A. S. Hamilton, Department of Preventive Medicine, University of Southern California, Los Angeles; J. W. Eley, Georgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA; L. C. Harlan, A. L. Potosky, Division of Cancer Control and Prevention, National Cancer Institute, Bethesda, MD; R. A. Stephenson, Utah Cancer Registry and Division of Urology, University of Utah School of Medicine, Salt Lake City; J. L. Stanford, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington; P. C. Albertson, Division of Urology, University of Connecticut Health Sciences Center, Farmington
J. William Eley - Affiliations of authors: R. M. Hoffman, Medicine Service, Department of Veterans Affairs Medical Center, Albuquerque, NM, and New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque; W. C. Hunt, New Mexico Tumor Registry, University of New Mexico Health Sciences Center; F. D. Gilliland, A. S. Hamilton, Department of Preventive Medicine, University of Southern California, Los Angeles; J. W. Eley, Georgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA; L. C. Harlan, A. L. Potosky, Division of Cancer Control and Prevention, National Cancer Institute, Bethesda, MD; R. A. Stephenson, Utah Cancer Registry and Division of Urology, University of Utah School of Medicine, Salt Lake City; J. L. Stanford, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington; P. C. Albertson, Division of Urology, University of Connecticut Health Sciences Center, Farmington
Linda C Harlan - Affiliations of authors: R. M. Hoffman, Medicine Service, Department of Veterans Affairs Medical Center, Albuquerque, NM, and New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque; W. C. Hunt, New Mexico Tumor Registry, University of New Mexico Health Sciences Center; F. D. Gilliland, A. S. Hamilton, Department of Preventive Medicine, University of Southern California, Los Angeles; J. W. Eley, Georgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA; L. C. Harlan, A. L. Potosky, Division of Cancer Control and Prevention, National Cancer Institute, Bethesda, MD; R. A. Stephenson, Utah Cancer Registry and Division of Urology, University of Utah School of Medicine, Salt Lake City; J. L. Stanford, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington; P. C. Albertson, Division of Urology, University of Connecticut Health Sciences Center, Farmington
Robert A Stephenson - Affiliations of authors: R. M. Hoffman, Medicine Service, Department of Veterans Affairs Medical Center, Albuquerque, NM, and New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque; W. C. Hunt, New Mexico Tumor Registry, University of New Mexico Health Sciences Center; F. D. Gilliland, A. S. Hamilton, Department of Preventive Medicine, University of Southern California, Los Angeles; J. W. Eley, Georgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA; L. C. Harlan, A. L. Potosky, Division of Cancer Control and Prevention, National Cancer Institute, Bethesda, MD; R. A. Stephenson, Utah Cancer Registry and Division of Urology, University of Utah School of Medicine, Salt Lake City; J. L. Stanford, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington; P. C. Albertson, Division of Urology, University of Connecticut Health Sciences Center, Farmington
Janet L Stanford - Affiliations of authors: R. M. Hoffman, Medicine Service, Department of Veterans Affairs Medical Center, Albuquerque, NM, and New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque; W. C. Hunt, New Mexico Tumor Registry, University of New Mexico Health Sciences Center; F. D. Gilliland, A. S. Hamilton, Department of Preventive Medicine, University of Southern California, Los Angeles; J. W. Eley, Georgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA; L. C. Harlan, A. L. Potosky, Division of Cancer Control and Prevention, National Cancer Institute, Bethesda, MD; R. A. Stephenson, Utah Cancer Registry and Division of Urology, University of Utah School of Medicine, Salt Lake City; J. L. Stanford, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington; P. C. Albertson, Division of Urology, University of Connecticut Health Sciences Center, Farmington
Peter C Albertson - Affiliations of authors: R. M. Hoffman, Medicine Service, Department of Veterans Affairs Medical Center, Albuquerque, NM, and New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque; W. C. Hunt, New Mexico Tumor Registry, University of New Mexico Health Sciences Center; F. D. Gilliland, A. S. Hamilton, Department of Preventive Medicine, University of Southern California, Los Angeles; J. W. Eley, Georgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA; L. C. Harlan, A. L. Potosky, Division of Cancer Control and Prevention, National Cancer Institute, Bethesda, MD; R. A. Stephenson, Utah Cancer Registry and Division of Urology, University of Utah School of Medicine, Salt Lake City; J. L. Stanford, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington; P. C. Albertson, Division of Urology, University of Connecticut Health Sciences Center, Farmington
Ann S Hamilton - Affiliations of authors: R. M. Hoffman, Medicine Service, Department of Veterans Affairs Medical Center, Albuquerque, NM, and New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque; W. C. Hunt, New Mexico Tumor Registry, University of New Mexico Health Sciences Center; F. D. Gilliland, A. S. Hamilton, Department of Preventive Medicine, University of Southern California, Los Angeles; J. W. Eley, Georgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA; L. C. Harlan, A. L. Potosky, Division of Cancer Control and Prevention, National Cancer Institute, Bethesda, MD; R. A. Stephenson, Utah Cancer Registry and Division of Urology, University of Utah School of Medicine, Salt Lake City; J. L. Stanford, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington; P. C. Albertson, Division of Urology, University of Connecticut Health Sciences Center, Farmington
W. Curtis Hunt - Affiliations of authors: R. M. Hoffman, Medicine Service, Department of Veterans Affairs Medical Center, Albuquerque, NM, and New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque; W. C. Hunt, New Mexico Tumor Registry, University of New Mexico Health Sciences Center; F. D. Gilliland, A. S. Hamilton, Department of Preventive Medicine, University of Southern California, Los Angeles; J. W. Eley, Georgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA; L. C. Harlan, A. L. Potosky, Division of Cancer Control and Prevention, National Cancer Institute, Bethesda, MD; R. A. Stephenson, Utah Cancer Registry and Division of Urology, University of Utah School of Medicine, Salt Lake City; J. L. Stanford, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington; P. C. Albertson, Division of Urology, University of Connecticut Health Sciences Center, Farmington
Arnold L Potosky - Affiliations of authors: R. M. Hoffman, Medicine Service, Department of Veterans Affairs Medical Center, Albuquerque, NM, and New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque; W. C. Hunt, New Mexico Tumor Registry, University of New Mexico Health Sciences Center; F. D. Gilliland, A. S. Hamilton, Department of Preventive Medicine, University of Southern California, Los Angeles; J. W. Eley, Georgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA; L. C. Harlan, A. L. Potosky, Division of Cancer Control and Prevention, National Cancer Institute, Bethesda, MD; R. A. Stephenson, Utah Cancer Registry and Division of Urology, University of Utah School of Medicine, Salt Lake City; J. L. Stanford, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, University of Washington; P. C. Albertson, Division of Urology, University of Connecticut Health Sciences Center, Farmington
Resource Type: Journal article
Publication Details: JNCI : Journal of the National Cancer Institute, Vol.93(5), pp.388-395
DOI: 10.1093/jnci/93.5.388
PMID: 11238701
NLM abbreviation: J Natl Cancer Inst
ISSN: 0027-8874
eISSN: 1460-2105
Publisher: Oxford University Press
Language: English
Date published: 03/07/2001
Academic Unit: Epidemiology; General Internal Medicine; Internal Medicine
Record Identifier: 9984094565702771

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